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    Gon4l gon-4 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gon4lprovided by RGD
    Official Full Name
    gon-4 likeprovided by RGD
    Primary source
    RGD:1564691
    See related
    EnsemblRapid:ENSRNOG00000020297 AllianceGenome:RGD:1564691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Yarp; Dingo
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within B cell differentiation. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 108.1), Thymus (RPKM 101.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gon4l in Genome Data Viewer
    Location:
    2q34
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176531274..176604446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174233461..174306636)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188139730..188212902)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Ras-like without CAAX 1 Neighboring gene synaptotagmin 11 Neighboring gene misato mitochondrial distribution and morphology regulator 1 Neighboring gene death associated protein 3 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. Lu P, et al. J Exp Med, 2010 Jul 5. PMID 20530203, Free PMC Article
    2. Cloning and expression analysis of YY1AP-related protein in the rat brain. Ohtomo T, et al. Amino Acids, 2008 Jan. PMID 17285227
    3. An anthropoid-specific segmental duplication on human chromosome 1q22. Kuryshev VY, et al. Genomics, 2006 Aug. PMID 16545939
    4. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. Lu P, et al. J Biol Chem, 2011 May 20. PMID 21454521, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GON-4-like protein
    Names
    GON-4 homolog
    YY1AP-related protein1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024797.1 → NP_001019968.1  GON-4-like protein

      See identical proteins and their annotated locations for NP_001019968.1

      Status: PROVISIONAL

      Source sequence(s)
      AY724781
      UniProtKB/Swiss-Prot
      Q535K7, Q535K8
      UniProtKB/TrEMBL
      A4PB69
      Related
      ENSRNOP00000069180.2, ENSRNOT00000077698.3
      Conserved Domains (2) summary
      cd12202
      Location:2158 → 2223
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1668 → 1713
      PAH; Paired amphipathic helix repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176531274..176604446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102906.2 → XP_038958834.1  GON-4-like protein isoform X11

      UniProtKB/TrEMBL
      D3ZMG1
      Conserved Domains (2) summary
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      PRK13108
      Location:1385 → 1511
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

    2. XM_039102893.2 → XP_038958821.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W6, A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2158 → 2223
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1668 → 1713
      PAH; Paired amphipathic helix repeat

    3. XM_039102904.2 → XP_038958832.1  GON-4-like protein isoform X9

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2092 → 2157
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1702 → 1728
      PAH; Paired amphipathic helix repeat

    4. XM_039102896.2 → XP_038958824.1  GON-4-like protein isoform X3

      UniProtKB/TrEMBL
      A4PB69
      Related
      ENSRNOP00000071608.2, ENSRNOT00000078913.3
      Conserved Domains (3) summary
      cd12202
      Location:2150 → 2215
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:983 → 1283
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1660 → 1705
      PAH; Paired amphipathic helix repeat

    5. XM_039102899.2 → XP_038958827.1  GON-4-like protein isoform X6

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (4) summary
      cd12202
      Location:2118 → 2183
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:951 → 1251
      PHA03247; large tegument protein UL36; Provisional
      PRK13108
      Location:1345 → 1471
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam02671
      Location:1628 → 1673
      PAH; Paired amphipathic helix repeat

    6. XM_039102894.2 → XP_038958822.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB69
      Related
      ENSRNOP00000110922.1, ENSRNOT00000160007.1
      Conserved Domains (3) summary
      cd12202
      Location:2157 → 2222
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:990 → 1290
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1667 → 1712
      PAH; Paired amphipathic helix repeat

    7. XM_039102897.2 → XP_038958825.1  GON-4-like protein isoform X4

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2149 → 2214
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:982 → 1282
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1659 → 1704
      PAH; Paired amphipathic helix repeat

    8. XM_039102900.2 → XP_038958828.1  GON-4-like protein isoform X7

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (4) summary
      cd12202
      Location:2117 → 2182
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:950 → 1250
      PHA03247; large tegument protein UL36; Provisional
      PRK13108
      Location:1344 → 1470
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam02671
      Location:1627 → 1672
      PAH; Paired amphipathic helix repeat

    9. XM_039102898.2 → XP_038958826.1  GON-4-like protein isoform X5

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2142 → 2207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:975 → 1275
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1652 → 1697
      PAH; Paired amphipathic helix repeat

    10. XM_039102903.2 → XP_038958831.1  GON-4-like protein isoform X8

      UniProtKB/TrEMBL
      A4PB69
      Related
      ENSRNOP00000100475.1, ENSRNOT00000148192.1
      Conserved Domains (4) summary
      cd12202
      Location:2094 → 2159
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:927 → 1227
      PHA03247; large tegument protein UL36; Provisional
      PRK13108
      Location:1321 → 1447
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam02671
      Location:1604 → 1649
      PAH; Paired amphipathic helix repeat

    11. XM_006232735.4 → XP_006232797.1  GON-4-like protein isoform X1

      See identical proteins and their annotated locations for XP_006232797.1

      UniProtKB/TrEMBL
      A0A0G2K0W6, A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2158 → 2223
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1668 → 1713
      PAH; Paired amphipathic helix repeat

    12. XM_039102902.2 → XP_038958830.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W6, A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2158 → 2223
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1668 → 1713
      PAH; Paired amphipathic helix repeat

    13. XM_063282373.1 → XP_063138443.1  GON-4-like protein isoform X5

      UniProtKB/TrEMBL
      A4PB69

    14. XM_063282374.1 → XP_063138444.1  GON-4-like protein isoform X8

      UniProtKB/TrEMBL
      A4PB69

    15. XM_039102901.2 → XP_038958829.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W6, A4PB69
      Conserved Domains (3) summary
      cd12202
      Location:2158 → 2223
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:991 → 1291
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1668 → 1713
      PAH; Paired amphipathic helix repeat

    16. XM_008761202.4 → XP_008759424.1  GON-4-like protein isoform X10

      UniProtKB/TrEMBL
      A4PB69
      Conserved Domains (2) summary
      cd12202
      Location:1987 → 2052
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1497 → 1542
      PAH; Paired amphipathic helix repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024804.1: Suppressed sequence

      Description
      NM_001024804.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q535K8.1 GenPept UniProtKB/Swiss-Prot:Q535K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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