Mgat5b alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mgat5bprovided by RGD
Official Full Name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Bprovided by RGD
Primary source: RGD:1305188
See related: EnsemblRapid:ENSRNOG00000024954 AllianceGenome:RGD:1305188
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Predicted to be involved in protein N-linked glycosylation and protein O-linked glycosylation via serine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 44.1), Thymus (RPKM 22.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102619559..102689023)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (102120757..102190235)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105861734..105932048)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10Rat4 (e-PCR), detects polymorphism
- UniSTS:226381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation via serine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Names: N-acetylglucosaminyltranferase VB; mannoside acetylglucosaminyltransferase 5, isoenzyme B; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B

NP_001100538.1

EC 2.4.1.155

XP_008766595.1

EC 2.4.1.155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107068.1 → NP_001100538.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

See identical proteins and their annotated locations for NP_001100538.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I6AL18, A6HL04, D3ZRS9

Conserved Domains (1) summary

pfam15024
Location:10 → 601

Glyco_transf_18; Glycosyltransferase family 18

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

102619559..102689023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768373.4 → XP_008766595.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1

UniProtKB/TrEMBL

A0A8I5ZTQ1, A0A8I6A8E1

Related

ENSRNOP00000081732.2, ENSRNOT00000096589.2

Conserved Domains (1) summary

pfam15024
Location:184 → 775

Glyco_transf_18; Glycosyltransferase family 18