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    SRCIN1 SRC kinase signaling inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 80725, updated on 10-Dec-2024

    Summary

    Official Symbol
    SRCIN1provided by HGNC
    Official Full Name
    SRC kinase signaling inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:29506
    See related
    Ensembl:ENSG00000277363 MIM:610786; AllianceGenome:HGNC:29506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P140; SNIP
    Summary
    Enables protein kinase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SRCIN1 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38530031..38607025, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39393085..39470208, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36686266..36762205, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36570079-36571013 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:36571014-36571949 and GRCh37_chr17:36571950-36572884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574173-36574722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574723-36575272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36575776-36576704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36577634-36578562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36580149-36580794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36584872-36585780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36585781-36586688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36592213-36592713 Neighboring gene Rho GTPase activating protein 23 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36597014-36597516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36605280-36606221 Neighboring gene uncharacterized LOC101929494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36607163-36608104 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36614287-36614452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36616590-36617218 Neighboring gene Sharpr-MPRA regulatory region 7659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36621073-36621864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36625516-36626152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36628374-36628874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36640731-36641252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649489-36649990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649991-36650490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655308-36655834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655835-36656359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665002-36665819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665820-36666636 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36706969-36707178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36717306-36717859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36718413-36718965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36718966-36719517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36719518-36720070 Neighboring gene uncharacterized LOC105371761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36720624-36721176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36721177-36721728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36722271-36722779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36734639-36735366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36735367-36736094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36748159-36748740 Neighboring gene uncharacterized LOC124903992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749033-36749534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749535-36750034 Neighboring gene Sharpr-MPRA regulatory region 8854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763065-36763666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763667-36764267 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36765411-36766081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36775868-36776378 Neighboring gene Sharpr-MPRA regulatory region 2012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36814959-36815458 Neighboring gene Sharpr-MPRA regulatory region 11404 Neighboring gene Sharpr-MPRA regulatory region 8107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36829618-36830453 Neighboring gene Sharpr-MPRA regulatory region 4536 Neighboring gene uncharacterized LOC105371763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36858367-36858898 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene microRNA 4734

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • KIAA1684

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton PubMed 
    located_in axon  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in dendrite  
    NOT located_in focal adhesion PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    located_in presynapse  
    located_in synapse  

    General protein information

    Preferred Names
    SRC kinase signaling inhibitor 1
    Names
    P130Cas-associated protein
    SNAP-25-interacting protein
    SNAP25-interacting protein
    p140Cap

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025248.3NP_079524.2  SRC kinase signaling inhibitor 1

      See identical proteins and their annotated locations for NP_079524.2

      Status: VALIDATED

      Source sequence(s)
      AC006449, AC115090, AC129916
      Consensus CDS
      CCDS45660.1
      UniProtKB/Swiss-Prot
      Q75T46, Q8N4W8, Q9C0H9
      UniProtKB/TrEMBL
      A0A087X165
      Related
      ENSP00000484715.1, ENST00000617146.5
      Conserved Domains (2) summary
      cl25732
      Location:686840
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27222
      Location:184263
      AIP3; Actin interacting protein 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      38530031..38607025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025169.2XP_016880658.1  SRC kinase signaling inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A087X165
    2. XM_017025172.2XP_016880661.1  SRC kinase signaling inhibitor 1 isoform X5

      UniProtKB/TrEMBL
      A0A087X165
    3. XM_017025171.2XP_016880660.1  SRC kinase signaling inhibitor 1 isoform X3

      UniProtKB/TrEMBL
      A0A087X165
    4. XM_017025170.2XP_016880659.1  SRC kinase signaling inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      A0A087X165
    5. XM_047436852.1XP_047292808.1  SRC kinase signaling inhibitor 1 isoform X7

      UniProtKB/TrEMBL
      A0A087X165
    6. XM_017025173.2XP_016880662.1  SRC kinase signaling inhibitor 1 isoform X6

      UniProtKB/TrEMBL
      A0A087X165
    7. XM_047436851.1XP_047292807.1  SRC kinase signaling inhibitor 1 isoform X4

      UniProtKB/TrEMBL
      A0A087X165
      Related
      ENST00000621763.4

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2565325..2642452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329377.1XP_054185352.1  SRC kinase signaling inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A087X165
    2. XM_054329379.1XP_054185354.1  SRC kinase signaling inhibitor 1 isoform X3

      UniProtKB/TrEMBL
      A0A087X165
    3. XM_054329378.1XP_054185353.1  SRC kinase signaling inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      A0A087X165
    4. XM_054329381.1XP_054185356.1  SRC kinase signaling inhibitor 1 isoform X5

      UniProtKB/TrEMBL
      A0A087X165
    5. XM_054329383.1XP_054185358.1  SRC kinase signaling inhibitor 1 isoform X7

      UniProtKB/TrEMBL
      A0A087X165
    6. XM_054329382.1XP_054185357.1  SRC kinase signaling inhibitor 1 isoform X6

      UniProtKB/TrEMBL
      A0A087X165
    7. XM_054329380.1XP_054185355.1  SRC kinase signaling inhibitor 1 isoform X4

      UniProtKB/TrEMBL
      A0A087X165

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      39393085..39470208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317415.1XP_054173390.1  SRC kinase signaling inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A087X165
    2. XM_054317417.1XP_054173392.1  SRC kinase signaling inhibitor 1 isoform X3

      UniProtKB/TrEMBL
      A0A087X165
    3. XM_054317416.1XP_054173391.1  SRC kinase signaling inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      A0A087X165
    4. XM_054317419.1XP_054173394.1  SRC kinase signaling inhibitor 1 isoform X5

      UniProtKB/TrEMBL
      A0A087X165
    5. XM_054317421.1XP_054173396.1  SRC kinase signaling inhibitor 1 isoform X7

      UniProtKB/TrEMBL
      A0A087X165
    6. XM_054317420.1XP_054173395.1  SRC kinase signaling inhibitor 1 isoform X6

      UniProtKB/TrEMBL
      A0A087X165
    7. XM_054317418.1XP_054173393.1  SRC kinase signaling inhibitor 1 isoform X4

      UniProtKB/TrEMBL
      A0A087X165
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