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    TCA17 Tca17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TCA17
    Official Full Name
    Tca17p
    Primary source
    SGD:S000000774
    Locus tag
    YEL048C
    See related
    AllianceGenome:SGD:S000000774; FungiDB:YEL048C; VEuPathDB:YEL048C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in early endosome to Golgi transport and protein-containing complex assembly. Located in Golgi apparatus. Part of TRAPPII protein complex. Used to study myoclonic-atonic epilepsy and rhabdomyolysis-myalgia syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TCA17 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (64709..65167, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene seripauperin PAU2 Neighboring gene fumarate reductase Neighboring gene threonine aldolase GLY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the yeast TRAPP-associated protein Tca17. Wang C, et al. FEBS J, 2014 Sep. PMID 24961828
    2. Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts. Milev MP, et al. J Med Genet, 2018 Nov. PMID 30120216
    3. TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. Scrivens PJ, et al. Traffic, 2009 Jun. PMID 19416478
    4. The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. Thomas LL, et al. J Cell Biol, 2018 Jan 2. PMID 29109089, Free PMC Article
    5. GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis. Thomas LL, et al. J Cell Biol, 2016 Nov 21. PMID 27872253, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The three-dimensional structure of yeast Tca17.
      Title: Crystal structure of the yeast TRAPP-associated protein Tca17.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tca17p
    NP_010866.1
    • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      64709..65167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178863.1 → NP_010866.1  TPA: Tca17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLK2, P32613, Q6Q561
      UniProtKB/TrEMBL
      A6ZQQ3, B3LRW9, C7GKF0, C8Z6U6, G2WCI6, N1P3R1
      Conserved Domains (1) summary
      cl21566
      Location:10 → 143
      Sedlin_N; Sedlin, N-terminal conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32613.1

    Gene LinkOut

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