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    GAK cyclin G associated kinase [ Homo sapiens (human) ]

    Gene ID: 2580, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GAKprovided by HGNC
    Official Full Name
    cyclin G associated kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:4113
    See related
    Ensembl:ENSG00000178950 MIM:602052; AllianceGenome:HGNC:4113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNAJ26; DNAJC26
    Summary
    In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in testis (RPKM 16.1), colon (RPKM 15.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GAK in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (849277..932316, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (847030..930388, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (843065..926104, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:860125-861324 Neighboring gene uncharacterized LOC105374341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:872957-874156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:880593-881094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:881095-881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:905677-906582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:906583-907488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:938924-939517 Neighboring gene transmembrane protein 175 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:957241-957400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:961731-962444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:962445-963158 Neighboring gene uncharacterized LOC124900645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:963506-964024 Neighboring gene diacylglycerol kinase theta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. He K, et al. J Cell Biol, 2020 Mar 2. PMID 31962345, Free PMC Article
    2. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Susa M, et al. Mol Cancer Ther, 2010 Dec. PMID 20881269
    3. Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly. Tanenbaum ME, et al. Chromosoma, 2010 Aug. PMID 20237935, Free PMC Article
    4. Genetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study. Tseng WE, et al. PLoS One, 2013. PMID 23826309, Free PMC Article
    5. Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Dumitriu A, et al. Hum Mol Genet, 2011 Apr 15. PMID 21258085, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
      Title: GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
    2. Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
      Title: Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
    3. Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
      Title: Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
    4. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
      Title: Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
    5. These findings indicate that the abnormal mitoses seen after silencing OIP5-AS1 were caused by an untimely rise in GAK levels and suggest that OIP5-AS1 suppresses cell proliferation at least in part by reducing GAK levels.
      Title: LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.
    6. that the multiple single nucleotide polymorphisms of GAK synergistically participate in the pathogenesis of sporadic Parkinson's disease through multiple pathways.
      Title: The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
    7. We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7-GAK inhibition increases multipolar mitoses
      Title: RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
    8. GAK gene expression is increased in Parkinson disease
      Title: The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.
    9. These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system.
      Title: GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.
    10. We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005).
      Title: Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
    EBI GWAS Catalog
    Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
    EBI GWAS Catalog
    Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
    EBI GWAS Catalog
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with cyclin G associated kinase (GAK) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16629, FLJ40395, MGC99654

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-folding chaperone binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin coat assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of clathrin coat assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle uncoating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-G-associated kinase
    Names
    auxilin-2
    dnaJ homolog subfamily C member 26
    NP_001305063.1
    NP_005246.2
    XP_005272325.1
    XP_005272327.1
    XP_011511727.1
    XP_011511728.1
    XP_011511729.1
    XP_011511730.1
    XP_011511731.1
    XP_011511732.1
    XP_011511733.1
    XP_011511734.1
    XP_011511736.1
    XP_016863480.1
    XP_016863481.1
    XP_016863482.1
    XP_016863483.1
    XP_047305958.1
    XP_047305959.1
    XP_047305960.1
    XP_047305961.1
    XP_047305962.1
    XP_047305963.1
    XP_047305964.1
    XP_047305966.1
    XP_047305967.1
    XP_047305968.1
    XP_047305969.1
    XP_047305970.1
    XP_047305971.1
    XP_047305972.1
    XP_047305974.1
    XP_047305975.1
    XP_047305976.1
    XP_047305977.1
    XP_047305978.1
    XP_047305979.1
    XP_047305980.1
    XP_047305981.1
    XP_047305982.1
    XP_047305984.1
    XP_047305985.1
    XP_047305986.1
    XP_047305987.1
    XP_047305988.1
    XP_047305989.1
    XP_047305990.1
    XP_047305991.1
    XP_054205549.1
    XP_054205550.1
    XP_054205551.1
    XP_054205552.1
    XP_054205553.1
    XP_054205554.1
    XP_054205555.1
    XP_054205556.1
    XP_054205557.1
    XP_054205558.1
    XP_054205559.1
    XP_054205560.1
    XP_054205561.1
    XP_054205562.1
    XP_054205563.1
    XP_054205564.1
    XP_054205565.1
    XP_054205566.1
    XP_054205567.1
    XP_054205568.1
    XP_054205569.1
    XP_054205570.1
    XP_054205571.1
    XP_054205572.1
    XP_054205573.1
    XP_054205574.1
    XP_054205575.1
    XP_054205576.1
    XP_054205577.1
    XP_054205578.1
    XP_054205579.1
    XP_054205580.1
    XP_054205581.1
    XP_054205582.1
    XP_054205583.1
    XP_054205584.1
    XP_054205585.1
    XP_054205586.1
    XP_054205587.1
    XP_054205588.1
    XP_054205589.1
    XP_054205590.1
    XP_054205591.1
    XP_054205592.1
    XP_054205593.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318134.2 → NP_001305063.1  cyclin-G-associated kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons in the 5' coding region but maintains the same reading frame as variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AA287110, AI138676, AK299554, BC000816, BC085005
      Consensus CDS
      CCDS82902.1
      UniProtKB/TrEMBL
      B4DS37
      Related
      ENSP00000421361.1, ENST00000511163.5
      Conserved Domains (4) summary
      cd06257
      Location:1181 → 1225
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:53 → 230
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:491 → 629
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:46 → 241
      PKc_like; Protein Kinases, catalytic domain

    2. NM_005255.4 → NP_005246.2  cyclin-G-associated kinase isoform 1

      See identical proteins and their annotated locations for NP_005246.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA287110, AI138676, BC000816, D88435, DA680073
      Consensus CDS
      CCDS3340.1
      UniProtKB/Swiss-Prot
      O14976, Q5U4P5, Q9BVY6
      UniProtKB/TrEMBL
      B4DS37
      Related
      ENSP00000314499.4, ENST00000314167.9
      Conserved Domains (4) summary
      cd06257
      Location:1260 → 1304
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      849277..932316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450032.1 → XP_047305988.1  cyclin-G-associated kinase isoform X41

      UniProtKB/TrEMBL
      B4DS37

    2. XM_047450022.1 → XP_047305978.1  cyclin-G-associated kinase isoform X32

      UniProtKB/TrEMBL
      B4DS37

    3. XM_047450019.1 → XP_047305975.1  cyclin-G-associated kinase isoform X28

      UniProtKB/TrEMBL
      B4DS37

    4. XM_017007992.2 → XP_016863481.1  cyclin-G-associated kinase isoform X17

      UniProtKB/TrEMBL
      B4DS37

    5. XM_047450028.1 → XP_047305984.1  cyclin-G-associated kinase isoform X37

      UniProtKB/TrEMBL
      B4DS37

    6. XM_047450024.1 → XP_047305980.1  cyclin-G-associated kinase isoform X34

      UniProtKB/TrEMBL
      B4DS37

    7. XM_047450025.1 → XP_047305981.1  cyclin-G-associated kinase isoform X35

      UniProtKB/TrEMBL
      B4DS37

    8. XM_047450031.1 → XP_047305987.1  cyclin-G-associated kinase isoform X40

      UniProtKB/TrEMBL
      B4DS37

    9. XM_047450015.1 → XP_047305971.1  cyclin-G-associated kinase isoform X24

      UniProtKB/TrEMBL
      B4DS37

    10. XM_047450004.1 → XP_047305960.1  cyclin-G-associated kinase isoform X12

      UniProtKB/TrEMBL
      B4DS37

    11. XM_047450021.1 → XP_047305977.1  cyclin-G-associated kinase isoform X31

      UniProtKB/TrEMBL
      B4DS37

    12. XM_047450029.1 → XP_047305985.1  cyclin-G-associated kinase isoform X38

      UniProtKB/TrEMBL
      B4DS37

    13. XM_011513430.2 → XP_011511732.1  cyclin-G-associated kinase isoform X8

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1225 → 1269
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:53 → 230
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:491 → 629
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:46 → 241
      PKc_like; Protein Kinases, catalytic domain

    14. XM_011513434.3 → XP_011511736.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1168 → 1212
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1 → 173
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:434 → 572
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1 → 184
      PKc_like; Protein Kinases, catalytic domain

    15. XM_047450030.1 → XP_047305986.1  cyclin-G-associated kinase isoform X39

      UniProtKB/TrEMBL
      Q59HA5

    16. XM_047450012.1 → XP_047305968.1  cyclin-G-associated kinase isoform X21

      UniProtKB/TrEMBL
      B4DS37

    17. XM_047450002.1 → XP_047305958.1  cyclin-G-associated kinase isoform X10

      UniProtKB/TrEMBL
      Q59HA5

    18. XM_047450010.1 → XP_047305966.1  cyclin-G-associated kinase isoform X18

      UniProtKB/TrEMBL
      B4DS37

    19. XM_017007991.2 → XP_016863480.1  cyclin-G-associated kinase isoform X7

      UniProtKB/TrEMBL
      B4DS37

    20. XM_011513427.3 → XP_011511729.1  cyclin-G-associated kinase isoform X3

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1274 → 1318
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:540 → 678
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:39 → 290
      PKc_like; Protein Kinases, catalytic domain

    21. XM_047450018.1 → XP_047305974.1  cyclin-G-associated kinase isoform X27

      UniProtKB/TrEMBL
      Q59HA5

    22. XM_047450026.1 → XP_047305982.1  cyclin-G-associated kinase isoform X36

      UniProtKB/TrEMBL
      Q59HA5

    23. XM_047450007.1 → XP_047305963.1  cyclin-G-associated kinase isoform X15

      UniProtKB/TrEMBL
      Q59HA5

    24. XM_047450014.1 → XP_047305970.1  cyclin-G-associated kinase isoform X23

      UniProtKB/TrEMBL
      B4DS37

    25. XM_047450023.1 → XP_047305979.1  cyclin-G-associated kinase isoform X33

      UniProtKB/TrEMBL
      B4DS37

    26. XM_047450005.1 → XP_047305961.1  cyclin-G-associated kinase isoform X13

      UniProtKB/TrEMBL
      B4DS37

    27. XM_011513428.3 → XP_011511730.1  cyclin-G-associated kinase isoform X4

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1255 → 1299
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    28. XM_047450006.1 → XP_047305962.1  cyclin-G-associated kinase isoform X14

      UniProtKB/TrEMBL
      Q59HA5

    29. XM_047450013.1 → XP_047305969.1  cyclin-G-associated kinase isoform X22

      UniProtKB/TrEMBL
      Q59HA5

    30. XM_005272268.3 → XP_005272325.1  cyclin-G-associated kinase isoform X5

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1249 → 1293
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    31. XM_011513426.3 → XP_011511728.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1293 → 1337
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    32. XM_011513431.3 → XP_011511733.1  cyclin-G-associated kinase isoform X9

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1221 → 1265
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    33. XM_005272270.3 → XP_005272327.1  cyclin-G-associated kinase isoform X20

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1185 → 1229
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    34. XM_011513425.3 → XP_011511727.1  cyclin-G-associated kinase isoform X1

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:1304 → 1348
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570 → 708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    35. XM_017007993.2 → XP_016863482.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1168 → 1212
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1 → 173
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:434 → 572
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1 → 184
      PKc_like; Protein Kinases, catalytic domain

    36. XM_011513432.3 → XP_011511734.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1216 → 1260
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1 → 221
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:482 → 620
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1 → 232
      PKc_like; Protein Kinases, catalytic domain

    37. XM_047450020.1 → XP_047305976.1  cyclin-G-associated kinase isoform X29

      UniProtKB/TrEMBL
      Q59HA5

    38. XM_047450003.1 → XP_047305959.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5

    39. XM_047450016.1 → XP_047305972.1  cyclin-G-associated kinase isoform X25

      UniProtKB/TrEMBL
      Q59HA5

    40. XM_011513429.3 → XP_011511731.1  cyclin-G-associated kinase isoform X6

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:1242 → 1286
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:24 → 247
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:508 → 646
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:25 → 258
      PKc_like; Protein Kinases, catalytic domain

    41. XM_047450011.1 → XP_047305967.1  cyclin-G-associated kinase isoform X19

      UniProtKB/TrEMBL
      Q59HA5

    42. XM_047450008.1 → XP_047305964.1  cyclin-G-associated kinase isoform X16

      UniProtKB/TrEMBL
      Q59HA5

    43. XM_047450034.1 → XP_047305990.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5

    44. XM_047450035.1 → XP_047305991.1  cyclin-G-associated kinase isoform X43

      UniProtKB/TrEMBL
      Q59HA5

    45. XM_047450033.1 → XP_047305989.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5

    46. XM_017007994.2 → XP_016863483.1  cyclin-G-associated kinase isoform X30

      UniProtKB/TrEMBL
      B4DS37

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      847030..930388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349615.1 → XP_054205590.1  cyclin-G-associated kinase isoform X41

      UniProtKB/TrEMBL
      B4DS37

    2. XM_054349606.1 → XP_054205581.1  cyclin-G-associated kinase isoform X32

      UniProtKB/TrEMBL
      B4DS37

    3. XM_054349602.1 → XP_054205577.1  cyclin-G-associated kinase isoform X28

      UniProtKB/TrEMBL
      B4DS37

    4. XM_054349590.1 → XP_054205565.1  cyclin-G-associated kinase isoform X17

      UniProtKB/TrEMBL
      B4DS37

    5. XM_054349611.1 → XP_054205586.1  cyclin-G-associated kinase isoform X37

      UniProtKB/TrEMBL
      B4DS37

    6. XM_054349608.1 → XP_054205583.1  cyclin-G-associated kinase isoform X34

      UniProtKB/TrEMBL
      B4DS37

    7. XM_054349609.1 → XP_054205584.1  cyclin-G-associated kinase isoform X35

      UniProtKB/TrEMBL
      B4DS37

    8. XM_054349614.1 → XP_054205589.1  cyclin-G-associated kinase isoform X40

      UniProtKB/TrEMBL
      B4DS37

    9. XM_054349597.1 → XP_054205572.1  cyclin-G-associated kinase isoform X24

      UniProtKB/TrEMBL
      B4DS37

    10. XM_054349585.1 → XP_054205560.1  cyclin-G-associated kinase isoform X12

      UniProtKB/TrEMBL
      B4DS37

    11. XM_054349605.1 → XP_054205580.1  cyclin-G-associated kinase isoform X31

      UniProtKB/TrEMBL
      B4DS37

    12. XM_054349612.1 → XP_054205587.1  cyclin-G-associated kinase isoform X38

      UniProtKB/TrEMBL
      B4DS37

    13. XM_054349581.1 → XP_054205556.1  cyclin-G-associated kinase isoform X8

      UniProtKB/TrEMBL
      B4DS37

    14. XM_054349600.1 → XP_054205575.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5

    15. XM_054349613.1 → XP_054205588.1  cyclin-G-associated kinase isoform X39

      UniProtKB/TrEMBL
      Q59HA5

    16. XM_054349594.1 → XP_054205569.1  cyclin-G-associated kinase isoform X21

      UniProtKB/TrEMBL
      B4DS37

    17. XM_054349583.1 → XP_054205558.1  cyclin-G-associated kinase isoform X10

      UniProtKB/TrEMBL
      Q59HA5

    18. XM_054349591.1 → XP_054205566.1  cyclin-G-associated kinase isoform X18

      UniProtKB/TrEMBL
      B4DS37

    19. XM_054349580.1 → XP_054205555.1  cyclin-G-associated kinase isoform X7

      UniProtKB/TrEMBL
      B4DS37

    20. XM_054349576.1 → XP_054205551.1  cyclin-G-associated kinase isoform X3

      UniProtKB/TrEMBL
      B4DS37

    21. XM_054349601.1 → XP_054205576.1  cyclin-G-associated kinase isoform X27

      UniProtKB/TrEMBL
      Q59HA5

    22. XM_054349610.1 → XP_054205585.1  cyclin-G-associated kinase isoform X36

      UniProtKB/TrEMBL
      Q59HA5

    23. XM_054349588.1 → XP_054205563.1  cyclin-G-associated kinase isoform X15

      UniProtKB/TrEMBL
      Q59HA5

    24. XM_054349596.1 → XP_054205571.1  cyclin-G-associated kinase isoform X23

      UniProtKB/TrEMBL
      B4DS37

    25. XM_054349607.1 → XP_054205582.1  cyclin-G-associated kinase isoform X33

      UniProtKB/TrEMBL
      B4DS37

    26. XM_054349586.1 → XP_054205561.1  cyclin-G-associated kinase isoform X13

      UniProtKB/TrEMBL
      B4DS37

    27. XM_054349577.1 → XP_054205552.1  cyclin-G-associated kinase isoform X4

      UniProtKB/TrEMBL
      B4DS37

    28. XM_054349587.1 → XP_054205562.1  cyclin-G-associated kinase isoform X14

      UniProtKB/TrEMBL
      Q59HA5

    29. XM_054349595.1 → XP_054205570.1  cyclin-G-associated kinase isoform X22

      UniProtKB/TrEMBL
      Q59HA5

    30. XM_054349578.1 → XP_054205553.1  cyclin-G-associated kinase isoform X5

      UniProtKB/TrEMBL
      Q59HA5

    31. XM_054349575.1 → XP_054205550.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      Q59HA5

    32. XM_054349582.1 → XP_054205557.1  cyclin-G-associated kinase isoform X9

      UniProtKB/TrEMBL
      B4DS37

    33. XM_054349593.1 → XP_054205568.1  cyclin-G-associated kinase isoform X20

      UniProtKB/TrEMBL
      B4DS37

    34. XM_054349574.1 → XP_054205549.1  cyclin-G-associated kinase isoform X1

      UniProtKB/TrEMBL
      B4DS37

    35. XM_054349599.1 → XP_054205574.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5

    36. XM_054349584.1 → XP_054205559.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5

    37. XM_054349603.1 → XP_054205578.1  cyclin-G-associated kinase isoform X29

      UniProtKB/TrEMBL
      Q59HA5

    38. XM_054349598.1 → XP_054205573.1  cyclin-G-associated kinase isoform X25

      UniProtKB/TrEMBL
      Q59HA5

    39. XM_054349579.1 → XP_054205554.1  cyclin-G-associated kinase isoform X6

      UniProtKB/TrEMBL
      Q59HA5

    40. XM_054349592.1 → XP_054205567.1  cyclin-G-associated kinase isoform X19

      UniProtKB/TrEMBL
      Q59HA5

    41. XM_054349589.1 → XP_054205564.1  cyclin-G-associated kinase isoform X16

      UniProtKB/TrEMBL
      Q59HA5

    42. XM_054349617.1 → XP_054205592.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5

    43. XM_054349618.1 → XP_054205593.1  cyclin-G-associated kinase isoform X43

      UniProtKB/TrEMBL
      Q59HA5

    44. XM_054349616.1 → XP_054205591.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5

    45. XM_054349604.1 → XP_054205579.1  cyclin-G-associated kinase isoform X30

      UniProtKB/TrEMBL
      B4DS37

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001286833.1: Suppressed sequence

      Description
      NM_001286833.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14976.2 GenPept UniProtKB/Swiss-Prot:O14976

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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