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    MAOB monoamine oxidase B [ Homo sapiens (human) ]

    Gene ID: 4129, updated on 10-Dec-2024

    Summary

    Official Symbol
    MAOBprovided by HGNC
    Official Full Name
    monoamine oxidase Bprovided by HGNC
    Primary source
    HGNC:HGNC:6834
    See related
    Ensembl:ENSG00000069535 MIM:309860; AllianceGenome:HGNC:6834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in liver (RPKM 72.6), ovary (RPKM 62.8) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MAOB in Genome Data Viewer
    Location:
    Xp11.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (43766610..43882450, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (43172827..43288647, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (43625857..43741696, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene MPRA-validated peak7375 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:43309398-43310202 Neighboring gene MPRA-validated peak7376 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chrX:43514055-43514449 Neighboring gene monoamine oxidase A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43808655-43809172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43809173-43809689 Neighboring gene NDP antisense RNA 1 Neighboring gene norrin cystine knot growth factor NDP Neighboring gene RBM39 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26382

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables primary methylamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables primary methylamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables primary methylamine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dopamine catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hydrogen peroxide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phenylethylamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substantia nigra development HEP PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial envelope TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    amine oxidase [flavin-containing] B
    Names
    MAO, brain
    MAO, platelet
    MAO-B
    adrenalin oxidase
    monoamine oxidase type B
    tyramine oxidase
    NP_000889.3
    XP_016885013.1
    XP_054183044.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008723.2 RefSeqGene

      Range
      5026..120866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000898.5NP_000889.3  amine oxidase [flavin-containing] B

      See identical proteins and their annotated locations for NP_000889.3

      Status: REVIEWED

      Source sequence(s)
      AL133791, BM726427, DC326844, M69177
      Consensus CDS
      CCDS14261.1
      UniProtKB/Swiss-Prot
      B2R6R3, B7Z5H3, D3DWC3, P27338, Q7Z6S2
      UniProtKB/TrEMBL
      Q8TBI1
      Related
      ENSP00000367309.4, ENST00000378069.5
      Conserved Domains (1) summary
      pfam01593
      Location:14451
      Amino_oxidase; Flavin containing amine oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      43766610..43882450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029524.3XP_016885013.1  amine oxidase [flavin-containing] B isoform X1

      UniProtKB/TrEMBL
      B7Z242, Q8TBI1
      Conserved Domains (2) summary
      pfam01593
      Location:1435
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:159
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      43172827..43288647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327069.1XP_054183044.1  amine oxidase [flavin-containing] B isoform X1

      UniProtKB/TrEMBL
      B7Z242, Q8TBI1