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    ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 6483, updated on 14-Dec-2024

    Summary

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    Official Symbol
    ST3GAL2provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:10863
    See related
    Ensembl:ENSG00000157350 MIM:607188; AllianceGenome:HGNC:10863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIAT4B; ST3GALII; Gal-NAc6S; ST3GalA.2
    Summary
    The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 6.9), spleen (RPKM 6.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ST3GAL2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70375977..70439100, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76187004..76250128, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70409880..70473003, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 19B Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70379806-70380424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70380425-70381042 Neighboring gene DEAD-box helicase 19A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70421141-70421825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11057 Neighboring gene uncharacterized LOC124903707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70458653-70459478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70461771-70462462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70462463-70463152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70464537-70465228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70467433-70467993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7673 Neighboring gene ribosomal protein S27 pseudogene 26 Neighboring gene RNA, U6 small nuclear 23, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. Saito S, et al. J Biol Chem, 2003 Jul 18. PMID 12716912
    2. Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. Taniguchi A, et al. Biochem Biophys Res Commun, 2003 Jan 10. PMID 12504121
    3. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). Kim YJ, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920913
    4. Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II. Ruggiero FM, et al. Biochem J, 2015 Jul 1. PMID 25916169
    5. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation. Zhang N, et al. Blood Adv, 2022 Jul 12. PMID 35507766, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
      Title: Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
    2. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status.
      Title: Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation.
    3. This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum
      Title: Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II.
    4. ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis
      Title: Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
    5. Genomic structure, expression, and transcriptional regulation of ST3GALII.
      Title: Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in globoside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in lipid glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Names
    Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    SIAT4-B
    ST3Gal II
    alpha 2,3-ST 2
    beta-galactoside alpha-2,3-sialyltransferase 2
    monosialoganglioside sialyltransferase
    sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)
    NP_008858.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046942.1 RefSeqGene

      Range
      5001..64654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006927.4 → NP_008858.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

      See identical proteins and their annotated locations for NP_008858.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, AK127322, BC036777
      Consensus CDS
      CCDS10890.1
      UniProtKB/Swiss-Prot
      O00654, Q16842
      UniProtKB/TrEMBL
      B2R7K8, B3KXG9
      Related
      ENSP00000345477.2, ENST00000342907.3
      Conserved Domains (1) summary
      pfam00777
      Location:95 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      70375977..70439100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      76187004..76250128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16842.1 GenPept UniProtKB/Swiss-Prot:Q16842

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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