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    AGBL2 AGBL carboxypeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 79841, updated on 10-Dec-2024

    Summary

    Official Symbol
    AGBL2provided by HGNC
    Official Full Name
    AGBL carboxypeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:26296
    See related
    Ensembl:ENSG00000165923 MIM:617345; AllianceGenome:HGNC:26296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCP2
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See AGBL2 in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47659591..47715369, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47824574..47880377, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47681143..47736921, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3336 Neighboring gene mitochondrial carrier 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3337 Neighboring gene Sharpr-MPRA regulatory region 12296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4702 Neighboring gene formin binding protein 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:47787258-47788183 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47788184-47789108 Neighboring gene nucleoporin 160 Neighboring gene RNA, 5S ribosomal pseudogene 340

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (11 hits/1255 screens)

    EBI GWAS Catalog

    Description
    Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ23598

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity  
    enables metallocarboxypeptidase activity  
    enables protein binding PubMed 
    enables tubulin binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in protein side chain deglutamylation  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole PubMed 
    located_in ciliary basal body PubMed 
    is_active_in cytoplasm  
    located_in cytosol  
    is_active_in microtubule cytoskeleton  

    General protein information

    Preferred Names
    cytosolic carboxypeptidase 2
    Names
    ATP/GTP binding protein like 2
    cytoplasmic carboxypeptidase 2
    protein deglutamylase CCP2
    testis tissue sperm-binding protein Li 96mP
    NP_079059.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024783.4 → NP_079059.2  cytosolic carboxypeptidase 2

      See identical proteins and their annotated locations for NP_079059.2

      Status: VALIDATED

      Source sequence(s)
      AC021443, BC036234
      Consensus CDS
      CCDS7944.1
      UniProtKB/Swiss-Prot
      A8MPX2, Q53FV5, Q5U5Z8, Q8IV57, Q9H5C0
      UniProtKB/TrEMBL
      A0A140VKH9, A0AAG2TLR7
      Related
      ENSP00000435582.1, ENST00000525123.6
      Conserved Domains (2) summary
      cd06907
      Location:407 → 666
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam13900
      Location:105 → 120
      GVQW; Putative domain of unknown function

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      47659591..47715369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_019805496.1 Reference GRCh38.p14 PATCHES

      Range
      91958..147736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      47824574..47880377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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