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    CPS1-IT1 CPS1 intronic transcript 1 [ Homo sapiens (human) ]

    Gene ID: 29034, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CPS1-IT1provided by HGNC
    Official Full Name
    CPS1 intronic transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:30102
    See related
    Ensembl:ENSG00000280837 AllianceGenome:HGNC:30102
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPS1IT; CPS1-IT; CPS1IT1; PRO0132
    Summary
    This gene does not encode a protein, and it is located within an intron of the gene encoding carbamoyl-phosphate synthetase 1. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See CPS1-IT1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (210617571..210619876)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (211098306..211100611)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (211482295..211484600)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LANCL1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:211225248-211226447 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:211229754-211230953 Neighboring gene myosin light chain 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:211294046-211295245 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211307490-211308075 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211346110-211346611 Neighboring gene LanC like glutathione S-transferase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211405459-211406038 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 1 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 2 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene uncharacterized LOC107985978 Neighboring gene 5'-nucleotidase domain containing 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LncRNA CPS1-IT1 serves as anti-oncogenic role in glioma. Chen H, et al. Biomed Pharmacother, 2019 Oct. PMID 31545272
    2. LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer. Zhang W, et al. Cell Physiol Biochem, 2017. PMID 29145177
    3. Long Noncoding RNA CPS1-IT1 Suppresses Cell Proliferation and Metastasis in Human Lung Cancer. Xiaoguang Z, et al. Oncol Res, 2017 Mar 13. PMID 27662619, Free PMC Article
    4. Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition. Wang TH, et al. Oncotarget, 2016 Jul 12. PMID 27248828, Free PMC Article
    5. Long noncoding RNA CPS1-IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1. Zhou X, et al. J Cell Physiol, 2019 Dec. PMID 31111478

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPS1-IT1 controls melanoma metastasis through impairing Cyr61 expression via competitively binding with BRG1
      Title: Long noncoding RNA CPS1-IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1.
    2. CPS1-IT1 plays an anti-oncogenic role in glioma.
      Title: LncRNA CPS1-IT1 serves as anti-oncogenic role in glioma.
    3. CPS1-IT1 suppresses tumor growth by reducing cell proliferation, migration and invasion capacities as well as by promoting cell apoptosis, thereby suppressing epithelial-mesenchymal transition.
      Title: LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer.
    4. LncRNA CPS1-IT1 acts as a tumor suppressor in hepatocellular carcinoma by reducing HIF-1alpha activation and suppressing epithelial-mesenchymal transition.
      Title: Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • CPS1 intronic transcript (non-protein coding)
    • CPS1 intronic transcript 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002763.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008172
      Related
      ENST00000628368.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      210617571..210619876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      211098306..211100611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014116.1: Suppressed sequence

      Description
      NM_014116.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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