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    FOXD3-AS1 FOXD3 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100996301, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FOXD3-AS1provided by HGNC
    Official Full Name
    FOXD3 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:40241
    See related
    Ensembl:ENSG00000230798 AllianceGenome:HGNC:40241
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAST; pasFOXD3
    Expression
    Biased expression in testis (RPKM 1.8), prostate (RPKM 0.5) and 11 other tissues See more
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    Genomic context

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    See FOXD3-AS1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (63320884..63324441, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63196549..63200106, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (63786555..63790112, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 466 Neighboring gene uncharacterized LOC105378770 Neighboring gene RNA, 5S ribosomal pseudogene 49 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:63663717-63664472 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:63664473-63665227 Neighboring gene VISTA enhancer hs764 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:63727542 Neighboring gene ribosomal protein SA pseudogene 65 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63751744-63752272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63752273-63752802 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63764905-63765721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63788679-63789368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:63792285-63793153 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63795855-63796783 Neighboring gene U7 small nuclear RNA Neighboring gene microRNA 6068 Neighboring gene forkhead box D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells. Chen ZH, et al. Am J Transl Res, 2016. PMID 27829996, Free PMC Article
    2. lncRNA FOXD3-AS1 is associated with clinical progression and regulates cell migration and invasion in breast cancer. Guan Y, et al. Cell Biochem Funct, 2019 Jun. PMID 31017311
    3. LncRNA FOXD3-AS1 promotes proliferation, invasion and migration of cutaneous malignant melanoma via regulating miR-325/MAP3K2. Chen X, et al. Biomed Pharmacother, 2019 Dec. PMID 31541886
    4. Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Guo CJ, et al. Cell, 2020 Apr 30. PMID 32259487
    5. Oncogenic Forkhead box D3 antisense RNA 1 promotes cell survival and confers temozolomide resistance in glioblastoma cells through the miR-128-3p/WEE1 G2 checkpoint kinase axis. Ling Z, et al. Bioengineered, 2022 Mar. PMID 35191808, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA FOXD3-AS1 Contributes to Glioblastoma Progression Via Sponging miR-3918 to Upregulate CCND1.
      Title: LncRNA FOXD3-AS1 Contributes to Glioblastoma Progression Via Sponging miR-3918 to Upregulate CCND1.
    2. Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
      Title: Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
    3. Mechanism of lncRNA FOXD3-AS1/miR-338-3p in the malignant progression of nasopharyngeal carcinoma through ceRNA.
      Title: Mechanism of lncRNA FOXD3-AS1/miR-338-3p in the malignant progression of nasopharyngeal carcinoma through ceRNA.
    4. LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression.
      Title: LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression.
    5. LncRNA FOXD3-AS1 promotes breast cancer progression by mediating ARF6.
      Title: LncRNA FOXD3-AS1 promotes breast cancer progression by mediating ARF6.
    6. Oncogenic Forkhead box D3 antisense RNA 1 promotes cell survival and confers temozolomide resistance in glioblastoma cells through the miR-128-3p/WEE1 G2 checkpoint kinase axis.
      Title: Oncogenic Forkhead box D3 antisense RNA 1 promotes cell survival and confers temozolomide resistance in glioblastoma cells through the miR-128-3p/WEE1 G2 checkpoint kinase axis.
    7. Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance.
      Title: Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance.
    8. Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation.
      Title: Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation.
    9. Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis.
      Title: Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis.
    10. FOXD3AS1/miR1283p/LIMK1 axis regulates cervical cancer progression.
      Title: FOXD3‑AS1/miR‑128‑3p/LIMK1 axis regulates cervical cancer progression.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • FOXD3 antisense RNA 1 (head to head)
    • FOXD3 antisense transcript 1'
    • FOXD3 promoter-associated antisense long non-coding RNA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_121634.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      KF925351, KF925352
      Related
      ENST00000418244.7

    2. NR_121635.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      KF925351
      Related
      ENST00000449386.7

    3. NR_121636.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and contains an alternate 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      HY065209, KF925350
      Related
      ENST00000431294.8

    4. NR_121637.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons and contains an alternate 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      KF925349
      Related
      ENST00000427268.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      63320884..63324441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      63196549..63200106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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