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    MIB2 MIB E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 142678, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIB2provided by HGNC
    Official Full Name
    MIB E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:30577
    See related
    Ensembl:ENSG00000197530 MIM:611141; AllianceGenome:HGNC:30577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZZZ5; ZZANK1
    Summary
    The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIB2 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1613731..1630605)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1048236..1065110)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1550880..1565985)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1505865-1506366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1511866-1512035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1512434-1512976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1529354-1530202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 80 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1534010-1534668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1534669-1535328 Neighboring gene uncharacterized LOC105378586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535329-1535988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535989-1536648 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1537005-1537147 Neighboring gene fibronectin type III domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 83 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 84 Neighboring gene uncharacterized LOC124903821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1565596-1566158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1568259-1569070 Neighboring gene matrix metallopeptidase 23B Neighboring gene cyclin dependent kinase 11B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1590308-1591030

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Takeuchi T, et al. Oncogene, 2006 Nov 9. PMID 16715130
    2. MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways. Kong Y, et al. Genes Genomics, 2023 Sep. PMID 37436668, Free PMC Article
    3. Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. Feltham R, et al. Cell Rep, 2018 Apr 10. PMID 29642005, Free PMC Article
    4. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. Takeuchi T, et al. DNA Cell Biol, 2005 May. PMID 15869411
    5. The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling. Rajan N, et al. Oncotarget, 2014 Dec 15. PMID 25565632, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways.
      Title: MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways.
    2. E3 ubiquitin-protein ligase 2 inhibits cell proliferation, migration, and invasion of non-small cell lung cancer through ubiquitination of Notch1.
      Title: E3 ubiquitin-protein ligase 2 inhibits cell proliferation, migration, and invasion of non-small cell lung cancer through ubiquitination of Notch1.
    3. MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL.
      Title: MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L).
    4. Results suggest that MIB2 enhances NF-kappaB signaling in inflammation by promoting the ubiquitin-dependent degradation of CYLD.
      Title: The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
    5. MIB2 represses the cytotoxic potential of RIPK1 by ubiquitylating lysine residues in the C-terminal portion of RIPK1. Disruption of MIB2-mediated ubiquitylation, either by mutation of MIB2's E3 activity or RIPK1's ubiquitin-acceptor lysines, sensitizes cells to RIPK1-mediated cell death.
      Title: Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.
    6. Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.
      Title: MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy.
    7. Here, we report a novel interaction between CYLD and MIB2 that supports the hypothesis that the CYLD/MIB2 interaction might play a pathogenic role in human cancer.
      Title: The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.
    8. The DLAIS motif in MAVS was found to be critical for MIB2 binding, the ligation of K63-linked ubiquitin to TANK-binding kinase 1, and phosphorylation-mediated IRF3/7 activation.
      Title: Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.
    9. identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway.
      Title: The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.
    10. Data identify Mind bomb-2 as an E3 ubiquitin ligase that interacts with and ubiquitinates the NR2B subunit of the NMDAR in mammalian cells.
      Title: Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20648, FLJ39787, FLJ41406

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MIB2
    Names
    RING-type E3 ubiquitin transferase MIB2
    mind bomb homolog 2
    mindbomb E3 ubiquitin protein ligase 2
    mindbomb homolog 2
    novel zinc finger protein
    novelzin
    putative NF-kappa-B-activating protein 002N
    skeletrophin
    zinc finger ZZ type with ankyrin repeat domain protein 1
    zinc finger, ZZ type with ankyrin repeat domain 1
    NP_001164157.3
    NP_001164158.3
    NP_001164159.2
    NP_001164160.1
    NP_543151.4
    XP_006710435.2
    XP_011539039.2
    XP_011539043.2
    XP_011539044.2
    XP_047302550.1
    XP_047302624.1
    XP_047302628.1
    XP_047302633.1
    XP_047302682.1
    XP_047302683.1
    XP_047302684.1
    XP_047302685.1
    XP_047302687.1
    XP_047302691.1
    XP_047302692.1
    XP_047302693.1
    XP_047302694.1
    XP_047302697.1
    XP_047302698.1
    XP_047302699.1
    XP_047302700.1
    XP_047302701.1
    XP_047302702.1
    XP_047302703.1
    XP_054190485.1
    XP_054190486.1
    XP_054190487.1
    XP_054190488.1
    XP_054190489.1
    XP_054190490.1
    XP_054190491.1
    XP_054190492.1
    XP_054190493.1
    XP_054190494.1
    XP_054190495.1
    XP_054190496.1
    XP_054190497.1
    XP_054190498.1
    XP_054190499.1
    XP_054190500.1
    XP_054190501.1
    XP_054190502.1
    XP_054190503.1
    XP_054190504.1
    XP_054190505.1
    XP_054190506.1
    XP_054190507.1
    XP_054190508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053090.1 RefSeqGene

      Range
      5313..20418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170686.4 → NP_001164157.3  E3 ubiquitin-protein ligase MIB2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Consensus CDS
      CCDS53261.2
      UniProtKB/TrEMBL
      A0A8C8USR6, B4DEI6
      Related
      ENSP00000428660.2, ENST00000520777.6
      Conserved Domains (8) summary
      PHA03095
      Location:457 → 708
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:461 → 491
      ANK; ANK repeat [structural motif]
      cd00162
      Location:907 → 939
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:827 → 863
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:906 → 951
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001170687.4 → NP_001164158.3  E3 ubiquitin-protein ligase MIB2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Consensus CDS
      CCDS41224.3
      UniProtKB/Swiss-Prot
      A2AGM5, A2AGM6, B3KV93, B3KVF4, B3KXY1, B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7, Q7Z437, Q8IY62, Q8N786, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1, Q96AX9
      UniProtKB/TrEMBL
      B4DEI6, E9PD12
      Related
      ENSP00000348081.6, ENST00000355826.10
      Conserved Domains (8) summary
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd00162
      Location:911 → 943
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:831 → 867
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:910 → 955
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_001170688.2 → NP_001164159.2  E3 ubiquitin-protein ligase MIB2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Consensus CDS
      CCDS53262.2
      UniProtKB/TrEMBL
      A0A8C8N694, B4DEI6
      Related
      ENSP00000428264.2, ENST00000518681.6
      Conserved Domains (8) summary
      PHA03095
      Location:396 → 647
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:400 → 430
      ANK; ANK repeat [structural motif]
      cd00162
      Location:846 → 878
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:766 → 802
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:12 → 78
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:263 → 327
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:845 → 890
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. NM_001170689.2 → NP_001164160.1  E3 ubiquitin-protein ligase MIB2 isoform 5

      See identical proteins and their annotated locations for NP_001164160.1

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Consensus CDS
      CCDS53264.1
      UniProtKB/TrEMBL
      D6RAZ0
      Related
      ENSP00000367984.1, ENST00000378712.5
      Conserved Domains (6) summary
      cd00204
      Location:398 → 510
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:12 → 77
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:404 → 496
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:491 → 542
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:400 → 430
      ANK; ANK repeat [structural motif]

    5. NM_080875.5 → NP_543151.4  E3 ubiquitin-protein ligase MIB2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Consensus CDS
      CCDS41224.3
      UniProtKB/Swiss-Prot
      A2AGM5, A2AGM6, B3KV93, B3KVF4, B3KXY1, B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7, Q7Z437, Q8IY62, Q8N786, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1, Q96AX9
      UniProtKB/TrEMBL
      B4DEI6, E9PD12
      Related
      ENSP00000426103.3, ENST00000505820.7
      Conserved Domains (8) summary
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd00162
      Location:911 → 943
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:831 → 867
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:910 → 955
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_033183.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL691432, FO704657
      Related
      ENST00000489635.5

    2. NR_146324.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL691432
      Related
      ENST00000463492.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1613731..1630605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446594.1 → XP_047302550.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    2. XM_047446668.1 → XP_047302624.1  E3 ubiquitin-protein ligase MIB2 isoform X3

    3. XM_047446726.1 → XP_047302682.1  E3 ubiquitin-protein ligase MIB2 isoform X7

    4. XM_047446727.1 → XP_047302683.1  E3 ubiquitin-protein ligase MIB2 isoform X8

    5. XM_047446677.1 → XP_047302633.1  E3 ubiquitin-protein ligase MIB2 isoform X4

    6. XM_047446729.1 → XP_047302685.1  E3 ubiquitin-protein ligase MIB2 isoform X10

    7. XM_047446731.1 → XP_047302687.1  E3 ubiquitin-protein ligase MIB2 isoform X11

      UniProtKB/TrEMBL
      B4DEI6

    8. XM_047446737.1 → XP_047302693.1  E3 ubiquitin-protein ligase MIB2 isoform X14

      UniProtKB/TrEMBL
      B4DEI6

    9. XM_047446744.1 → XP_047302700.1  E3 ubiquitin-protein ligase MIB2 isoform X19

      UniProtKB/TrEMBL
      B4DEI6

    10. XM_047446735.1 → XP_047302691.1  E3 ubiquitin-protein ligase MIB2 isoform X12

      UniProtKB/TrEMBL
      B4DEI6

    11. XM_006710372.2 → XP_006710435.2  E3 ubiquitin-protein ligase MIB2 isoform X20

      UniProtKB/TrEMBL
      F2Z2L2

    12. XM_047446736.1 → XP_047302692.1  E3 ubiquitin-protein ligase MIB2 isoform X13

      UniProtKB/TrEMBL
      B4DEI6

    13. XM_047446742.1 → XP_047302698.1  E3 ubiquitin-protein ligase MIB2 isoform X17

      UniProtKB/TrEMBL
      B4DEI6

    14. XM_047446738.1 → XP_047302694.1  E3 ubiquitin-protein ligase MIB2 isoform X15

      UniProtKB/TrEMBL
      B4DEI6

    15. XM_047446745.1 → XP_047302701.1  E3 ubiquitin-protein ligase MIB2 isoform X21

      UniProtKB/TrEMBL
      B4DEI6

    16. XM_047446741.1 → XP_047302697.1  E3 ubiquitin-protein ligase MIB2 isoform X16

      UniProtKB/TrEMBL
      B4DEI6

    17. XM_047446743.1 → XP_047302699.1  E3 ubiquitin-protein ligase MIB2 isoform X18

      UniProtKB/TrEMBL
      B4DEI6

    18. XM_047446746.1 → XP_047302702.1  E3 ubiquitin-protein ligase MIB2 isoform X22

      UniProtKB/TrEMBL
      F2Z2L2
      Related
      ENSP00000367980.1, ENST00000378708.5

    19. XM_011540737.4 → XP_011539039.2  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/TrEMBL
      H0YAM8

    20. XM_011540741.4 → XP_011539043.2  E3 ubiquitin-protein ligase MIB2 isoform X5

      UniProtKB/TrEMBL
      H0YAM8
      Related
      ENSP00000427680.1, ENST00000514234.5

    21. XM_011540742.4 → XP_011539044.2  E3 ubiquitin-protein ligase MIB2 isoform X6

      UniProtKB/TrEMBL
      H0YAM8

    22. XM_047446728.1 → XP_047302684.1  E3 ubiquitin-protein ligase MIB2 isoform X9

      UniProtKB/TrEMBL
      H0YAM8

    23. XM_047446672.1 → XP_047302628.1  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/TrEMBL
      H0YAM8

    24. XM_047446747.1 → XP_047302703.1  E3 ubiquitin-protein ligase MIB2 isoform X23

      UniProtKB/TrEMBL
      B4DEI6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1048236..1065110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334510.1 → XP_054190485.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    2. XM_054334512.1 → XP_054190487.1  E3 ubiquitin-protein ligase MIB2 isoform X3

    3. XM_054334517.1 → XP_054190492.1  E3 ubiquitin-protein ligase MIB2 isoform X7

    4. XM_054334518.1 → XP_054190493.1  E3 ubiquitin-protein ligase MIB2 isoform X8

    5. XM_054334514.1 → XP_054190489.1  E3 ubiquitin-protein ligase MIB2 isoform X4

    6. XM_054334520.1 → XP_054190495.1  E3 ubiquitin-protein ligase MIB2 isoform X10

    7. XM_054334521.1 → XP_054190496.1  E3 ubiquitin-protein ligase MIB2 isoform X11

      UniProtKB/TrEMBL
      B4DEI6

    8. XM_054334524.1 → XP_054190499.1  E3 ubiquitin-protein ligase MIB2 isoform X14

      UniProtKB/TrEMBL
      B4DEI6

    9. XM_054334529.1 → XP_054190504.1  E3 ubiquitin-protein ligase MIB2 isoform X19

      UniProtKB/TrEMBL
      B4DEI6

    10. XM_054334522.1 → XP_054190497.1  E3 ubiquitin-protein ligase MIB2 isoform X12

      UniProtKB/TrEMBL
      B4DEI6

    11. XM_054334530.1 → XP_054190505.1  E3 ubiquitin-protein ligase MIB2 isoform X20

      UniProtKB/TrEMBL
      F2Z2L2

    12. XM_054334523.1 → XP_054190498.1  E3 ubiquitin-protein ligase MIB2 isoform X13

      UniProtKB/TrEMBL
      B4DEI6

    13. XM_054334527.1 → XP_054190502.1  E3 ubiquitin-protein ligase MIB2 isoform X17

      UniProtKB/TrEMBL
      B4DEI6

    14. XM_054334525.1 → XP_054190500.1  E3 ubiquitin-protein ligase MIB2 isoform X15

      UniProtKB/TrEMBL
      B4DEI6

    15. XM_054334531.1 → XP_054190506.1  E3 ubiquitin-protein ligase MIB2 isoform X21

      UniProtKB/TrEMBL
      B4DEI6

    16. XM_054334526.1 → XP_054190501.1  E3 ubiquitin-protein ligase MIB2 isoform X16

      UniProtKB/TrEMBL
      B4DEI6

    17. XM_054334528.1 → XP_054190503.1  E3 ubiquitin-protein ligase MIB2 isoform X18

      UniProtKB/TrEMBL
      B4DEI6

    18. XM_054334532.1 → XP_054190507.1  E3 ubiquitin-protein ligase MIB2 isoform X22

      UniProtKB/TrEMBL
      F2Z2L2

    19. XM_054334511.1 → XP_054190486.1  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/TrEMBL
      H0YAM8

    20. XM_054334515.1 → XP_054190490.1  E3 ubiquitin-protein ligase MIB2 isoform X5

      UniProtKB/TrEMBL
      H0YAM8

    21. XM_054334516.1 → XP_054190491.1  E3 ubiquitin-protein ligase MIB2 isoform X6

      UniProtKB/TrEMBL
      H0YAM8

    22. XM_054334519.1 → XP_054190494.1  E3 ubiquitin-protein ligase MIB2 isoform X9

      UniProtKB/TrEMBL
      H0YAM8

    23. XM_054334513.1 → XP_054190488.1  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/TrEMBL
      H0YAM8

    24. XM_054334533.1 → XP_054190508.1  E3 ubiquitin-protein ligase MIB2 isoform X23

      UniProtKB/TrEMBL
      B4DEI6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AX9.4 GenPept UniProtKB/Swiss-Prot:Q96AX9

    Gene LinkOut

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