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    HAS3 hyaluronan synthase 3 [ Homo sapiens (human) ]

    Gene ID: 3038, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HAS3provided by HGNC
    Official Full Name
    hyaluronan synthase 3provided by HGNC
    Primary source
    HGNC:HGNC:4820
    See related
    Ensembl:ENSG00000103044 MIM:602428; AllianceGenome:HGNC:4820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
    Expression
    Broad expression in urinary bladder (RPKM 19.2), lung (RPKM 12.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HAS3 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69083484..69118719)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74879801..74915029)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69139556..69152622)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 6 homolog Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69096798-69097616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69105561-69106280 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69106281-69106998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69106999-69107717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69107718-69108435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69111819-69112338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69122977-69123854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69131715-69132540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69133965-69134466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7653 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene Sharpr-MPRA regulatory region 12307 Neighboring gene UTP4 small subunit processome component Neighboring gene RNA, U6 small nuclear 22, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. Bullard KM, et al. Int J Cancer, 2003 Dec 10. PMID 14566823
    2. HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder. Chang IW, et al. Tumour Biol, 2015 Jul. PMID 25934334
    3. Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion. Takabe P, et al. Exp Cell Res, 2015 Sep 10. PMID 26222208
    4. UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression. Deen AJ, et al. Cell Mol Life Sci, 2016 Aug. PMID 26883802, Free PMC Article
    5. Identification and analysis of the promoter region of the human HAS3 gene. Wang S, et al. Biochem Biophys Res Commun, 2015 May 15. PMID 25843802

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3.
      Title: Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3.
    2. Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis.
      Title: Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis.
    3. 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression.
      Title: 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression.
    4. Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
      Title: Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
    5. A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function.
      Title: A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function.
    6. Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling.
      Title: Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling.
    7. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
      Title: HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
    8. The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells.
      Title: The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells.
    9. There was a higher HAS1 and HAS2 reactivity and lower HAS3 reactivity in the PCOS endometrium compared to women with regular menstrual cycles in the proliferative phase.
      Title: Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.
    10. Study shows that HAS3 is induced by IL-1beta in vascular smooth muscle cells and that HAS3 is critically involved in early macrophage driven inflammation.
      Title: Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hyaluronan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronan synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hyaluronan synthase activity TAS
    Traceable Author Statement
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in extracellular matrix assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hyaluronan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hyaluronan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hyaluronan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hyaluronan biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polysaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of hyaluranon cable assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hyaluranon cable IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan synthase 3
    Names
    HA synthase 3
    hyaluronate synthase 3
    hyaluronic acid synthase 3
    NP_001186209.1
    NP_005320.2
    NP_619515.1
    XP_005255978.1
    XP_011521363.1
    XP_047290001.1
    XP_047290002.1
    XP_047290003.1
    XP_054236175.1
    XP_054236176.1
    XP_054236177.1
    XP_054236178.1
    XP_054236179.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047056.2 RefSeqGene

      Range
      27171..39178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199280.2 → NP_001186209.1  hyaluronan synthase 3 isoform a

      See identical proteins and their annotated locations for NP_001186209.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Both variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AC009027, AK291400
      Consensus CDS
      CCDS10871.1
      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2
      Related
      ENSP00000454731.1, ENST00000569188.6
      Conserved Domains (1) summary
      cd06434
      Location:86 → 364
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    2. NM_005329.3 → NP_005320.2  hyaluronan synthase 3 isoform a

      See identical proteins and their annotated locations for NP_005320.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains a different 5' exon as compared to variant 3. Both variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AC009027, AF234839
      Consensus CDS
      CCDS10871.1
      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2
      Related
      ENSP00000304440.1, ENST00000306560.1
      Conserved Domains (1) summary
      cd06434
      Location:86 → 364
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    3. NM_138612.3 → NP_619515.1  hyaluronan synthase 3 isoform b

      See identical proteins and their annotated locations for NP_619515.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a different 5' and 3' exon as compared to variant 3. As a result, variant 2 encodes isoform b, which has the same N-terminus but is shorter and has a different C-terminus than isoform a encoded by variant 3.
      Source sequence(s)
      AC009027, BC021853
      Consensus CDS
      CCDS10870.1
      UniProtKB/TrEMBL
      H3BRH5
      Related
      ENSP00000219322.3, ENST00000219322.7
      Conserved Domains (1) summary
      cl11394
      Location:86 → 247
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      69083484..69118719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434047.1 → XP_047290003.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    2. XM_047434046.1 → XP_047290002.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    3. XM_047434045.1 → XP_047290001.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    4. XM_011523061.3 → XP_011521363.1  hyaluronan synthase 3 isoform X1

      See identical proteins and their annotated locations for XP_011521363.1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2
      Conserved Domains (1) summary
      cd06434
      Location:86 → 364
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    5. XM_005255921.3 → XP_005255978.1  hyaluronan synthase 3 isoform X1

      See identical proteins and their annotated locations for XP_005255978.1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2
      Conserved Domains (1) summary
      cd06434
      Location:86 → 364
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      74879801..74915029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380204.1 → XP_054236179.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    2. XM_054380203.1 → XP_054236178.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    3. XM_054380202.1 → XP_054236177.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    4. XM_054380200.1 → XP_054236175.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2

    5. XM_054380201.1 → XP_054236176.1  hyaluronan synthase 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T5, O00219, Q8WTZ0, Q9NYP0
      UniProtKB/TrEMBL
      Q96RV2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00219.3 GenPept UniProtKB/Swiss-Prot:O00219

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