SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [Homo sapiens (human)] - Gene

Summary

Official Symbol: SUGT1provided by HGNC
Official Full Name: SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by HGNC
Primary source: HGNC:HGNC:16987
See related: Ensembl:ENSG00000165416 MIM:604098; AllianceGenome:HGNC:16987
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGT1
Summary: This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
Expression: Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (52652836..52700909)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (51868272..51916337)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (53226971..53275044)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sgt1 Regulates alpha-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.
Title: Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.
SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
Title: SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1
Title: Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.
the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere.
Title: SGT1-HSP90 complex is required for CENP-A deposition at centromeres.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1)
Title: Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha.
Title: Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli.
Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A.
Title: Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1.
Title: The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.
our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer
Title: SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.
Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42926 (e-PCR)
- UniSTS:94826

RH78334 (e-PCR)
- UniSTS:73072

1342 (e-PCR)
- UniSTS:62066

SHGC-58486 (e-PCR)
- UniSTS:94363

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein SGT1 homolog

Names: SGT1, suppressor of G2 allele of SKP1; putative 40-6-3 protein; suppressor of G2 allele of SKP1, S. cerevisiae, homolog of

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029521.3 RefSeqGene

Range

5002..53075

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130912.3 → NP_001124384.1 protein SGT1 homolog isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B).

Source sequence(s)

AL139089

Consensus CDS

CCDS45050.1

UniProtKB/Swiss-Prot

A2A303, Q5JAK5, Q5TAM6, Q6VXY6, Q9Y2Z0

UniProtKB/TrEMBL

A8K5T7

Related

ENSP00000367208.4, ENST00000343788.10

Conserved Domains (2) summary

PLN03088
Location:21 → 365

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:44 → 74

TPR; TPR repeat [structural motif]
NM_001320831.2 → NP_001307760.1 protein SGT1 homolog isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.

Source sequence(s)

AL139089

UniProtKB/TrEMBL

B4DYC6

Conserved Domains (2) summary

sd00006
Location:22 → 52

TPR; TPR repeat [structural motif]

cl26005
Location:8 → 277

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
NM_006704.5 → NP_006695.1 protein SGT1 homolog isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B.

Source sequence(s)

AL139089

Consensus CDS

CCDS9436.1

UniProtKB/TrEMBL

A8K7W3

Related

ENSP00000308067.7, ENST00000310528.9

Conserved Domains (2) summary

sd00006
Location:44 → 74

TPR; TPR repeat [structural motif]

cl26005
Location:21 → 333

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional