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    FGFR1OP2 FGFR1 oncogene partner 2 [ Homo sapiens (human) ]

    Gene ID: 26127, updated on 9-Dec-2024

    Summary

    Official Symbol
    FGFR1OP2provided by HGNC
    Official Full Name
    FGFR1 oncogene partner 2provided by HGNC
    Primary source
    HGNC:HGNC:23098
    See related
    Ensembl:ENSG00000111790 MIM:608858; AllianceGenome:HGNC:23098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WIT3.0; HSPC123-like
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 23.0), adrenal (RPKM 22.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FGFR1OP2 in Genome Data Viewer
    Location:
    12p11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (26938470..26966648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (26810479..26838658)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27091403..27119581)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor type 2 Neighboring gene enoyl-CoA hydratase domain containing 2 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_27003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4305 Neighboring gene Sharpr-MPRA regulatory region 14818 Neighboring gene MPRA-validated peak1624 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:27037949-27038123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:27091219-27091728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:27091729-27092237 Neighboring gene integrator complex subunit 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4307 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6131 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37569, DKFZp564O1863, DKFZp586C1423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in response to wounding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    FGFR1 oncogene partner 2
    Names
    fibroblast growth factor receptor 1 oncogene partner 2
    wound inducible transcript 3.0

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171887.2NP_001165358.1  FGFR1 oncogene partner 2 isoform 2

      See identical proteins and their annotated locations for NP_001165358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC024896, BI829470, DA388639
      Consensus CDS
      CCDS53767.1
      UniProtKB/Swiss-Prot
      Q9NVK5
      Related
      ENSP00000323763.5, ENST00000327214.5
      Conserved Domains (1) summary
      pfam05769
      Location:2183
      SIKE; SIKE family
    2. NM_001171888.2NP_001165359.1  FGFR1 oncogene partner 2 isoform 3

      See identical proteins and their annotated locations for NP_001165359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC024896, AK001534, BC032143
      Consensus CDS
      CCDS53766.1
      UniProtKB/Swiss-Prot
      Q9NVK5
      Related
      ENSP00000437556.1, ENST00000546072.5
      Conserved Domains (1) summary
      pfam05769
      Location:2133
      DUF837; Protein of unknown function (DUF837)
    3. NM_015633.3NP_056448.1  FGFR1 oncogene partner 2 isoform 1

      See identical proteins and their annotated locations for NP_056448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC024896, AK001534
      Consensus CDS
      CCDS8709.1
      UniProtKB/Swiss-Prot
      Q6R955, Q8N5L7, Q9NVK5, Q9P034, Q9UFK8
      Related
      ENSP00000229395.3, ENST00000229395.8
      Conserved Domains (1) summary
      pfam05769
      Location:2221
      SIKE; SIKE family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      26938470..26966648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      26810479..26838658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)