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    PRR15L proline rich 15 like [ Homo sapiens (human) ]

    Gene ID: 79170, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PRR15Lprovided by HGNC
    Official Full Name
    proline rich 15 likeprovided by HGNC
    Primary source
    HGNC:HGNC:28149
    See related
    Ensembl:ENSG00000167183 AllianceGenome:HGNC:28149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATAD4
    Expression
    Biased expression in duodenum (RPKM 78.9), small intestine (RPKM 58.5) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR15L in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47951967..47957883, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48813758..48819670, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46029333..46035249, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45977450-45977954 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45978459-45978962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45979467-45979970 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45981458-45981651 Neighboring gene SP2 antisense RNA 1 Neighboring gene Sp2 transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46004735-46005236 Neighboring gene Sharpr-MPRA regulatory region 5948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12320 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46033917-46034862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46034863-46035808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46048841-46049468 Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46052765-46053265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46072377-46072975 Neighboring gene Sharpr-MPRA regulatory region 8372 Neighboring gene uncharacterized LOC124904017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12321

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. EPICURE Consortium, et al. Hum Mol Genet, 2012 Dec 15. PMID 22949513
    2. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article
    3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11242

    General protein information

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    Preferred Names
    proline-rich protein 15-like protein
    Names
    ATPase family, AAA domain containing 4
    testicular tissue protein Li 157

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024320.4 → NP_077296.1  proline-rich protein 15-like protein

      See identical proteins and their annotated locations for NP_077296.1

      Status: VALIDATED

      Source sequence(s)
      AA707319, AA916635, AC018521, BM829856, BM831136
      Consensus CDS
      CCDS11523.1
      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
      Related
      ENSP00000300557.2, ENST00000300557.3
      Conserved Domains (1) summary
      pfam15321
      Location:7 → 88
      ATAD4; ATPase family AAA domain containing 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      47951967..47957883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257663.5 → XP_005257720.1  proline-rich protein 15-like protein isoform X1

      See identical proteins and their annotated locations for XP_005257720.1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
      Conserved Domains (1) summary
      pfam15321
      Location:7 → 88
      ATAD4; ATPase family AAA domain containing 4

    2. XM_005257666.5 → XP_005257723.1  proline-rich protein 15-like protein isoform X1

      See identical proteins and their annotated locations for XP_005257723.1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
      Conserved Domains (1) summary
      pfam15321
      Location:7 → 88
      ATAD4; ATPase family AAA domain containing 4

    3. XM_047436740.1 → XP_047292696.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1

    4. XM_005257664.2 → XP_005257721.1  proline-rich protein 15-like protein isoform X1

      See identical proteins and their annotated locations for XP_005257721.1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
      Conserved Domains (1) summary
      pfam15321
      Location:7 → 88
      ATAD4; ATPase family AAA domain containing 4

    5. XM_005257665.1 → XP_005257722.1  proline-rich protein 15-like protein isoform X1

      See identical proteins and their annotated locations for XP_005257722.1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
      Conserved Domains (1) summary
      pfam15321
      Location:7 → 88
      ATAD4; ATPase family AAA domain containing 4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      48813758..48819670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317200.1 → XP_054173175.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1

    2. XM_054317201.1 → XP_054173176.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1

    3. XM_054317202.1 → XP_054173177.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1

    4. XM_054317203.1 → XP_054173178.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1

    5. XM_054317204.1 → XP_054173179.1  proline-rich protein 15-like protein isoform X1

      UniProtKB/Swiss-Prot
      D3DTU0, Q9BU68
      UniProtKB/TrEMBL
      A0A140VJT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BU68.1 GenPept UniProtKB/Swiss-Prot:Q9BU68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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