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    MTERF1 mitochondrial transcription termination factor 1 [ Homo sapiens (human) ]

    Gene ID: 7978, updated on 3-Dec-2024

    Summary

    Official Symbol
    MTERF1provided by HGNC
    Official Full Name
    mitochondrial transcription termination factor 1provided by HGNC
    Primary source
    HGNC:HGNC:21463
    See related
    Ensembl:ENSG00000127989 MIM:602318; AllianceGenome:HGNC:21463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTERF
    Summary
    This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 5.6), appendix (RPKM 4.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MTERF1 in Genome Data Viewer
    Location:
    7q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (91870929..91880702, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (93112226..93122026, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91500243..91510016, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:91285565-91286066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:91302583-91303084 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:91381695-91382196 Neighboring gene uncharacterized LOC124901696 Neighboring gene uncharacterized LOC112267986 Neighboring gene uncharacterized LOC124901698 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:91569717-91570278

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    transcription termination factor 1, mitochondrial
    Names
    transcription termination factor, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301134.2NP_001288063.1  transcription termination factor 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001288063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC003086, AK222730, AL832861, BC130391, BU740531
      Consensus CDS
      CCDS75629.1
      UniProtKB/TrEMBL
      B2R952, B4DPR9
      Related
      ENSP00000414116.1, ENST00000419292.1
      Conserved Domains (1) summary
      pfam02536
      Location:56369
      mTERF; mTERF
    2. NM_001301135.2NP_001288064.1  transcription termination factor 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001288064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC003086, AK222730, AK298469, BU740531
      Consensus CDS
      CCDS75629.1
      UniProtKB/TrEMBL
      B2R952, B4DPR9
      Related
      ENSP00000384986.2, ENST00000406735.6
      Conserved Domains (1) summary
      pfam02536
      Location:56369
      mTERF; mTERF
    3. NM_006980.5NP_008911.1  transcription termination factor 1, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_008911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC003086, AK222730, BC130391, BU740531
      Consensus CDS
      CCDS5621.1
      UniProtKB/Swiss-Prot
      A4D1E3, Q32NF8, Q53H51, Q99551, Q9BVR7
      UniProtKB/TrEMBL
      B2R952
      Related
      ENSP00000248643.3, ENST00000351870.8
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      91870929..91880702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250593.4XP_005250650.1  transcription termination factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005250650.1

      UniProtKB/Swiss-Prot
      A4D1E3, Q32NF8, Q53H51, Q99551, Q9BVR7
      UniProtKB/TrEMBL
      B2R952
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF
    2. XM_006716126.4XP_006716189.1  transcription termination factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006716189.1

      UniProtKB/Swiss-Prot
      A4D1E3, Q32NF8, Q53H51, Q99551, Q9BVR7
      UniProtKB/TrEMBL
      B2R952
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF
    3. XM_047420839.1XP_047276795.1  transcription termination factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B2R952, B4DPR9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      93112226..93122026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359006.1XP_054214981.1  transcription termination factor 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2R952
    2. XM_054359007.1XP_054214982.1  transcription termination factor 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2R952
    3. XM_054359008.1XP_054214983.1  transcription termination factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B2R952