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    CDC6 cell division cycle 6 [ Homo sapiens (human) ]

    Gene ID: 990, updated on 3-Dec-2024

    Summary

    Official Symbol
    CDC6provided by HGNC
    Official Full Name
    cell division cycle 6provided by HGNC
    Primary source
    HGNC:HGNC:1744
    See related
    Ensembl:ENSG00000094804 MIM:602627; AllianceGenome:HGNC:1744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC18L; HsCDC6; MGORS5; HsCDC18
    Summary
    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDC6 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40287879..40304657)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41151103..41168161)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38444131..38460909)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38350695-38351195 Neighboring gene microRNA 6867 Neighboring gene Sharpr-MPRA regulatory region 10842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:38375397-38376175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38380779-38381350 Neighboring gene WAS/WASL interacting protein family member 2 Neighboring gene RNY4 pseudogene 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38437298-38438234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38438235-38439169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38443891-38444698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38447656-38448242 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:38452145-38452660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38464859-38465744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38465745-38466628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38468218-38468718 Neighboring gene uncharacterized LOC105371934 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38473742-38473951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38477303-38477887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12143 Neighboring gene retinoic acid receptor alpha Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38497666-38498244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498280-38498830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498831-38499380 Neighboring gene RARA antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleotide binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vasopressin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in traversing start control point of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division control protein 6 homolog
    Names
    CDC6 cell division cycle 6 homolog
    CDC6-related protein
    cdc18-related protein
    cell division cycle 6 homolog
    p62(cdc6)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028240.2 RefSeqGene

      Range
      5001..21779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1257

    mRNA and Protein(s)

    1. NM_001254.4NP_001245.1  cell division control protein 6 homolog

      See identical proteins and their annotated locations for NP_001245.1

      Status: REVIEWED

      Source sequence(s)
      AC080112, AK313620, BC025232
      Consensus CDS
      CCDS11365.1
      UniProtKB/Swiss-Prot
      Q8TB30, Q99741
      UniProtKB/TrEMBL
      B2R935
      Related
      ENSP00000209728.4, ENST00000209728.9
      Conserved Domains (3) summary
      smart01074
      Location:465545
      Cdc6_C; CDC6, C terminal
      COG1474
      Location:168547
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:171314
      AAA_16; AAA ATPase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40287879..40304657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525542.2XP_011523844.1  cell division control protein 6 homolog isoform X1

      See identical proteins and their annotated locations for XP_011523844.1

      UniProtKB/TrEMBL
      B2R935
      Conserved Domains (3) summary
      smart01074
      Location:505585
      Cdc6_C; CDC6, C terminal
      COG1474
      Location:168587
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:171314
      AAA_16; AAA ATPase domain
    2. XM_047437207.1XP_047293163.1  cell division control protein 6 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q8TB30, Q99741
      UniProtKB/TrEMBL
      B2R935
    3. XM_011525541.3XP_011523843.1  cell division control protein 6 homolog isoform X1

      See identical proteins and their annotated locations for XP_011523843.1

      UniProtKB/TrEMBL
      B2R935
      Conserved Domains (3) summary
      smart01074
      Location:505585
      Cdc6_C; CDC6, C terminal
      COG1474
      Location:168587
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:171314
      AAA_16; AAA ATPase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41151103..41168161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318058.1XP_054174033.1  cell division control protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      B2R935
    2. XM_054318059.1XP_054174034.1  cell division control protein 6 homolog isoform X2

      UniProtKB/TrEMBL
      B2R935
    3. XM_054318057.1XP_054174032.1  cell division control protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      B2R935