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    SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

    Gene ID: 6783, updated on 9-Dec-2024

    Summary

    Official Symbol
    SULT1E1provided by HGNC
    Official Full Name
    sulfotransferase family 1E member 1provided by HGNC
    Primary source
    HGNC:HGNC:11377
    See related
    Ensembl:ENSG00000109193 MIM:600043; AllianceGenome:HGNC:11377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EST; STE; EST-1; ST1E1
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SULT1E1 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69821122..69860145, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73176039..73194989, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725863, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1B member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70608551-70609050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609253-70609754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609755-70610254 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15467 Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene casein alpha s1 Neighboring gene casein beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables estrone sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    sulfotransferase 1E1
    Names
    estrogen sulfotransferase
    estrone sulfotransferase
    sulfotransferase family 1E, estrogen-preferring, member 1
    sulfotransferase, estrogen-preferring
    NP_005411.1
    XP_011530512.1
    XP_047272056.1
    XP_047272057.1
    XP_054206726.1
    XP_054206727.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005420.3NP_005411.1  sulfotransferase 1E1

      See identical proteins and their annotated locations for NP_005411.1

      Status: REVIEWED

      Source sequence(s)
      AC108941
      Consensus CDS
      CCDS3531.1
      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91
      Related
      ENSP00000226444.3, ENST00000226444.4
      Conserved Domains (1) summary
      pfam00685
      Location:37287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69821122..69860145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416101.1XP_047272057.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91
    2. XM_047416100.1XP_047272056.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91
    3. XM_011532210.3XP_011530512.1  sulfotransferase 1E1 isoform X2

      Conserved Domains (1) summary
      pfam00685
      Location:37165
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. XR_007057952.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73176039..73194989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350751.1XP_054206726.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91
    2. XM_054350752.1XP_054206727.1  sulfotransferase 1E1 isoform X2