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    DCAKD dephospho-CoA kinase domain containing [ Homo sapiens (human) ]

    Gene ID: 79877, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DCAKDprovided by HGNC
    Official Full Name
    dephospho-CoA kinase domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:26238
    See related
    Ensembl:ENSG00000172992 AllianceGenome:HGNC:26238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 10.9), thyroid (RPKM 9.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCAKD in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45023338..45061131, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45877369..45915003, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43100706..43138499, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8605 Neighboring gene uncharacterized LOC107987243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43074788-43075540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43080963-43081726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43083016-43083972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43085503-43086003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43089992-43090778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12268 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43096740-43096919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43112912-43113412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43113413-43113913 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43117423-43118057 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43118058-43118692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43118693-43119327 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43120482-43121367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43121368-43122252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43124492-43125024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43125025-43125555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43137465-43138456 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43138457-43139448 Neighboring gene N-myristoyltransferase 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:43168092-43168593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175496-43175996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175997-43176497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43180894-43181394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43184227-43184728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43189298-43190163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43190164-43191028 Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
    2. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
    3. The shieldin complex mediates 53BP1-dependent DNA repair. Noordermeer SM, et al. Nature, 2018 Aug. PMID 30022168, Free PMC Article
    4. Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. Volkmar N, et al. EMBO J, 2022 Oct 4. PMID 35993436, Free PMC Article
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, et al. J Proteome Res, 2012 Feb 3. PMID 22053931

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22955

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    dephospho-CoA kinase domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128631.3 → NP_001122103.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001122103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000413483.1, ENST00000452796.7
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    2. NM_001288654.2 → NP_001275583.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001275583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AI497945, BC018132, BF115235, BX487139, HY061203
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000308515.5, ENST00000310604.9
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    3. NM_001288655.2 → NP_001275584.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001275584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000498268.1, ENST00000651974.1
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    4. NM_001321326.2 → NP_001308255.1  dephospho-CoA kinase domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000467913.1, ENST00000588499.6
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    5. NM_024819.7 → NP_079095.3  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_079095.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000341504.4, ENST00000342350.10
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45023338..45061131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525262.3 → XP_011523564.1  dephospho-CoA kinase domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011523564.1

      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1
      Related
      ENSP00000509802.1, ENST00000688897.1
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    2. XM_047436773.1 → XP_047292729.1  dephospho-CoA kinase domain-containing protein isoform X2

      Related
      ENSP00000509609.1, ENST00000687955.1

    3. XM_005257688.3 → XP_005257745.1  dephospho-CoA kinase domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_005257745.1

      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000510000.1, ENST00000592902.6
      Conserved Domains (2) summary
      COG0237
      Location:1 → 107
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cl17190
      Location:1 → 98
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. XM_017025103.2 → XP_016880592.1  dephospho-CoA kinase domain-containing protein isoform X2

      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000509434.1, ENST00000685986.1
      Conserved Domains (2) summary
      COG0237
      Location:1 → 107
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cl17190
      Location:1 → 98
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45877369..45915003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317266.1 → XP_054173241.1  dephospho-CoA kinase domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      A8K3Z0, D3DX60, D3DX62, Q8WVC6, Q9BR71, Q9H5W1

    2. XM_054317270.1 → XP_054173245.1  dephospho-CoA kinase domain-containing protein isoform X2

    3. XM_054317269.1 → XP_054173244.1  dephospho-CoA kinase domain-containing protein isoform X2

    4. XM_054317267.1 → XP_054173242.1  dephospho-CoA kinase domain-containing protein isoform X2

    5. XM_054317268.1 → XP_054173243.1  dephospho-CoA kinase domain-containing protein isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WVC6.1 GenPept UniProtKB/Swiss-Prot:Q8WVC6

    Gene LinkOut

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