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    ZNF608 zinc finger protein 608 [ Homo sapiens (human) ]

    Gene ID: 57507, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF608provided by HGNC
    Official Full Name
    zinc finger protein 608provided by HGNC
    Primary source
    HGNC:HGNC:29238
    See related
    Ensembl:ENSG00000168916 MIM:620972; AllianceGenome:HGNC:29238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NY-REN-36
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung (RPKM 4.4), testis (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF608 in Genome Data Viewer
    Location:
    5q23.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (124636915..124748824, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (125153362..125265304, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (123972608..124084517, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC107986448 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123644150-123645142 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80867 Neighboring gene uncharacterized LOC105379155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16277 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123777990-123778496 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:123804163-123805004 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123832600-123833191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:123833192-123833782 Neighboring gene NANOG hESC enhancer GRCh37_chr5:123837876-123838461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23009 Neighboring gene NANOG hESC enhancer GRCh37_chr5:123890213-123891101 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:123935182-123935396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23011 Neighboring gene Sharpr-MPRA regulatory region 9682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:123984206-123984714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23012 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123995996-123996689 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:123998129-123998646 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:124044787-124045526 Neighboring gene NANOG hESC enhancer GRCh37_chr5:124068918-124069490 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:124073123-124073732 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124074341-124074948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23013 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:124077846-124078540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:124079931-124080624 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124082573-124083571 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:124083572-124084570 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124086863-124087461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16279 Neighboring gene uncharacterized LOC105379156 Neighboring gene ribosomal protein L28 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese. Ma RC, et al. PLoS One, 2014. PMID 24465431, Free PMC Article
    2. Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells. Báez-Vega PM, et al. Oncotarget, 2016 Jun 14. PMID 27166999, Free PMC Article
    3. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Graff M, et al. Hum Mol Genet, 2013 Sep 1. PMID 23669352, Free PMC Article
    4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Kerns SL, et al. Int J Radiat Oncol Biol Phys, 2010 Dec 1. PMID 20932654, Free PMC Article
    5. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility. Manjur ABMK, et al. J Steroid Biochem Mol Biol, 2021 Jun. PMID 33722704

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
    EBI GWAS Catalog
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166851, DKFZp781C0723

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 608
    Names
    renal carcinoma antigen NY-REN-36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385619.1 → NP_001372548.1  zinc finger protein 608 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC112196, AC113398
      Consensus CDS
      CCDS34219.1
      UniProtKB/Swiss-Prot
      A7E2W9, Q3SYM6, Q68D12, Q8IY05, Q9ULD9, Q9Y5A1
      Related
      ENSP00000307746.5, ENST00000306315.9
      Conserved Domains (2) summary
      COG5189
      Location:512 → 593
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1103 → 1317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. NM_001385620.1 → NP_001372549.1  zinc finger protein 608 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112196, AC113398
      Conserved Domains (2) summary
      COG5189
      Location:512 → 593
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1103 → 1317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    3. NM_001385621.1 → NP_001372550.1  zinc finger protein 608 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112196, AC113398
      Conserved Domains (2) summary
      COG5189
      Location:224 → 305
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:815 → 1029
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    4. NM_020747.3 → NP_065798.2  zinc finger protein 608 isoform 1

      See identical proteins and their annotated locations for NP_065798.2

      Status: VALIDATED

      Source sequence(s)
      AC112196, AC113398
      Consensus CDS
      CCDS34219.1
      UniProtKB/Swiss-Prot
      A7E2W9, Q3SYM6, Q68D12, Q8IY05, Q9ULD9, Q9Y5A1
      Related
      ENSP00000421899.2, ENST00000513986.2
      Conserved Domains (2) summary
      COG5189
      Location:512 → 593
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1103 → 1317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      124636915..124748824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417448.1 → XP_047273404.1  zinc finger protein 608 isoform X5

      Related
      ENSP00000427657.1, ENST00000504926.5

    2. XM_011543522.4 → XP_011541824.1  zinc finger protein 608 isoform X2

      Conserved Domains (2) summary
      COG5189
      Location:215 → 296
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:806 → 1020
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    3. XM_011543523.3 → XP_011541825.1  zinc finger protein 608 isoform X4

      Conserved Domains (2) summary
      COG5189
      Location:127 → 208
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:718 → 932
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    4. XM_011543520.4 → XP_011541822.1  zinc finger protein 608 isoform X1

      Conserved Domains (2) summary
      COG5189
      Location:512 → 593
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1103 → 1317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    5. XM_047417447.1 → XP_047273403.1  zinc finger protein 608 isoform X3

    6. XM_047417446.1 → XP_047273402.1  zinc finger protein 608 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      125153362..125265304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353006.1 → XP_054208981.1  zinc finger protein 608 isoform X2

    2. XM_054353009.1 → XP_054208984.1  zinc finger protein 608 isoform X4

    3. XM_054353005.1 → XP_054208980.1  zinc finger protein 608 isoform X1

    4. XM_054353008.1 → XP_054208983.1  zinc finger protein 608 isoform X3

    5. XM_054353007.1 → XP_054208982.1  zinc finger protein 608 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULD9.4 GenPept UniProtKB/Swiss-Prot:Q9ULD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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