U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LRRC37A leucine rich repeat containing 37A [ Homo sapiens (human) ]

    Gene ID: 9884, updated on 10-Dec-2024

    Summary

    Official Symbol
    LRRC37Aprovided by HGNC
    Official Full Name
    leucine rich repeat containing 37Aprovided by HGNC
    Primary source
    HGNC:HGNC:29069
    See related
    Ensembl:ENSG00000176681 MIM:616555; AllianceGenome:HGNC:29069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC37; LRRC37A1
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 14.7), bone marrow (RPKM 4.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRRC37A in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46248044..46337794)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47110074..47199790)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44372497..44415160)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene KANSL1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44337043-44337589 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 1 Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene ARF like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene ARF like GTPase 17A Neighboring gene RDM1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 37A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014834.4NP_055649.4  leucine-rich repeat-containing protein 37A precursor

      See identical proteins and their annotated locations for NP_055649.4

      Status: VALIDATED

      Source sequence(s)
      AC005829, AC217777
      Consensus CDS
      CCDS11504.2
      UniProtKB/Swiss-Prot
      A6NMS7, Q68DY2, Q8IWC7
      UniProtKB/TrEMBL
      A0A0G2JNC9
      Related
      ENSP00000326324.5, ENST00000320254.5
      Conserved Domains (5) summary
      sd00031
      Location:891914
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:14681613
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      46248044..46337794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437205.1XP_047293161.1  leucine-rich repeat-containing protein 37A isoform X10

      UniProtKB/TrEMBL
      Q5YKG5
    2. XM_047437200.1XP_047293156.1  leucine-rich repeat-containing protein 37A isoform X4

      UniProtKB/TrEMBL
      A0A0G2JNC9
    3. XM_047437206.1XP_047293162.1  leucine-rich repeat-containing protein 37A isoform X9

      UniProtKB/TrEMBL
      A0A0J9YVT7, E9PP10
      Related
      ENSP00000437021.1, ENST00000496930.5
    4. XM_047437196.1XP_047293152.1  leucine-rich repeat-containing protein 37A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNC9
    5. XM_047437197.1XP_047293153.1  leucine-rich repeat-containing protein 37A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JNC9
    6. XM_047437198.1XP_047293154.1  leucine-rich repeat-containing protein 37A isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNC9
    7. XM_047437199.1XP_047293155.1  leucine-rich repeat-containing protein 37A isoform X5

      UniProtKB/TrEMBL
      A0A994J7J8
    8. XM_047437201.1XP_047293157.1  leucine-rich repeat-containing protein 37A isoform X6

      UniProtKB/TrEMBL
      A0A994J7J8
    9. XM_047437202.1XP_047293158.1  leucine-rich repeat-containing protein 37A isoform X7

    10. XM_047437204.1XP_047293160.1  leucine-rich repeat-containing protein 37A isoform X8

    11. XM_047437203.1XP_047293159.1  leucine-rich repeat-containing protein 37A isoform X11

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      413631..539475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328599.1XP_054184574.1  leucine-rich repeat-containing protein 37A isoform X10

      UniProtKB/TrEMBL
      Q5YKG5
    2. XM_054328591.1XP_054184566.1  leucine-rich repeat-containing protein 37A isoform X12

      UniProtKB/TrEMBL
      A0A0G2JNC9
    3. XM_054328590.1XP_054184565.1  leucine-rich repeat-containing protein 37A isoform X12

      UniProtKB/TrEMBL
      A0A0G2JNC9
    4. XM_054328600.1XP_054184575.1  leucine-rich repeat-containing protein 37A isoform X9

      UniProtKB/TrEMBL
      A0A0G2JQV0, A0A0G2JRA3
    5. XM_054328594.1XP_054184569.1  leucine-rich repeat-containing protein 37A isoform X4

      UniProtKB/TrEMBL
      A0A0G2JNC9
    6. XM_054328592.1XP_054184567.1  leucine-rich repeat-containing protein 37A isoform X13

      UniProtKB/TrEMBL
      A0A0G2JNC9
    7. XM_054328593.1XP_054184568.1  leucine-rich repeat-containing protein 37A isoform X5

      UniProtKB/TrEMBL
      A0A994J7J8
    8. XM_054328589.1XP_054184564.1  leucine-rich repeat-containing protein 37A isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNC9
    9. XM_054328588.1XP_054184563.1  leucine-rich repeat-containing protein 37A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JNC9
    10. XM_054328587.1XP_054184562.1  leucine-rich repeat-containing protein 37A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNC9
    11. XM_054328598.1XP_054184573.1  leucine-rich repeat-containing protein 37A isoform X14

    12. XM_054328597.1XP_054184572.1  leucine-rich repeat-containing protein 37A isoform X8

    13. XM_054328595.1XP_054184570.1  leucine-rich repeat-containing protein 37A isoform X7

    14. XM_054328596.1XP_054184571.1  leucine-rich repeat-containing protein 37A isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47110074..47199790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318056.1XP_054174031.1  leucine-rich repeat-containing protein 37A isoform X10

      UniProtKB/TrEMBL
      Q5YKG5
    2. XM_054318054.1XP_054174029.1  leucine-rich repeat-containing protein 37A isoform X16

      UniProtKB/TrEMBL
      A0A0J9YVT7
    3. XM_054318045.1XP_054174020.1  leucine-rich repeat-containing protein 37A isoform X15

      UniProtKB/TrEMBL
      A0A0G2JNC9
    4. XM_054318055.1XP_054174030.1  leucine-rich repeat-containing protein 37A isoform X9

      UniProtKB/TrEMBL
      A0A0J9YVT7
    5. XM_054318049.1XP_054174024.1  leucine-rich repeat-containing protein 37A isoform X4

      UniProtKB/TrEMBL
      A0A0G2JNC9
    6. XM_054318046.1XP_054174021.1  leucine-rich repeat-containing protein 37A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNC9
    7. XM_054318047.1XP_054174022.1  leucine-rich repeat-containing protein 37A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JNC9
    8. XM_054318048.1XP_054174023.1  leucine-rich repeat-containing protein 37A isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNC9
    9. XM_054318050.1XP_054174025.1  leucine-rich repeat-containing protein 37A isoform X5

      UniProtKB/TrEMBL
      A0A994J7J8
    10. XM_054318051.1XP_054174026.1  leucine-rich repeat-containing protein 37A isoform X6

      UniProtKB/TrEMBL
      A0A994J7J8
    11. XM_054318053.1XP_054174028.1  leucine-rich repeat-containing protein 37A isoform X8

    12. XM_054318052.1XP_054174027.1  leucine-rich repeat-containing protein 37A isoform X7