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    GPR162 G protein-coupled receptor 162 [ Homo sapiens (human) ]

    Gene ID: 27239, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPR162provided by HGNC
    Official Full Name
    G protein-coupled receptor 162provided by HGNC
    Primary source
    HGNC:HGNC:16693
    See related
    Ensembl:ENSG00000250510 AllianceGenome:HGNC:16693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A-2; GRCA
    Summary
    This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 25.8), lung (RPKM 3.5) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPR162 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6821821..6827421)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6831114..6836714)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6930987..6936586)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6898178-6898735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5883 Neighboring gene CD4 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928026-6928526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928527-6929027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6929998-6930970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: P3H3

    Clone Names

    • FLJ78837

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 162
    Names
    gene rich cluster, A
    gene-rich cluster gene A protein
    NP_055264.1
    NP_062832.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014449.2NP_055264.1  probable G-protein coupled receptor 162 isoform 1

      See identical proteins and their annotated locations for NP_055264.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A-1) differs in the 5' UTR and the 5' coding region, compared to variant A-2. The resulting isoform (1) contains a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      U47924, U47925
      Consensus CDS
      CCDS44819.1
      UniProtKB/TrEMBL
      Q96I00
      Related
      ENSP00000399670.2, ENST00000428545.6
      Conserved Domains (2) summary
      cd14964
      Location:1944
      7tm_GPCRs; TM helix 7 [structural motif]
      cl28897
      Location:651
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_019858.2NP_062832.1  probable G-protein coupled receptor 162 isoform 2

      See identical proteins and their annotated locations for NP_062832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A-2) represents the longer transcript, and encodes the longer isoform (2).
      Source sequence(s)
      U47924, U47928
      Consensus CDS
      CCDS8563.1
      UniProtKB/Swiss-Prot
      Q16538, Q16664, Q59EH5, Q66K56
      UniProtKB/TrEMBL
      A0A0I9QPQ8
      Related
      ENSP00000311528.3, ENST00000311268.8
      Conserved Domains (1) summary
      pfam00001
      Location:34207
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6821821..6827421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6831114..6836714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)