LAP2 bifunctional aminopeptidase/epoxide hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LAP2
Official Full Name: bifunctional aminopeptidase/epoxide hydrolase
Primary source: SGD:S000004990
Locus tag: YNL045W
See related: AllianceGenome:SGD:S000004990; FungiDB:YNL045W; VEuPathDB:YNL045W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aminopeptidase activity and epoxide hydrolase activity. Involved in cellular lipid metabolic process and protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LAP2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (542963..544978)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structures of both native leukotriene A4 hydrolase and the hydrolase in complex with bestatin were solved. These structures show leukotriene A4 is bound in a partially-obstruced protected cavity in the active site of the human hydrolase.
Title: A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding.
the conserved tyrosine residue of Saccharomyces cerevisiae leukotriene A4 hydrolase stabilizes the transition state of the peptidase activity
Title: A conserved tyrosine residue of Saccharomyces cerevisiae leukotriene A4 hydrolase stabilizes the transition state of the peptidase activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables epoxide hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables epoxide hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional aminopeptidase/epoxide hydrolase

NP_014353.1

EC 3.3.2.10

Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

542963..544978

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182884.1 → NP_014353.1 TPA: bifunctional aminopeptidase/epoxide hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014353.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZS33, D6W1D4, Q10740

UniProtKB/TrEMBL

C8ZGI3, G2WM58, N1NZJ8

Conserved Domains (1) summary

TIGR02411
Location:57 → 669

leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase