Gnas GNAS complex locus [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnasprovided by RGD
Official Full Name: GNAS complex locusprovided by RGD
Primary source: RGD:2716
See related: EnsemblRapid:ENSRNOG00000047374 EnsemblRapid:ENSRNOG00000080265 AllianceGenome:RGD:2716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALEX; SCG6; Gnas1; Gnpas; Nesp55; G-alpha-8
Summary: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2009]
Expression: Biased expression in Adrenal (RPKM 421.2), Thymus (RPKM 326.6) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3q43

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (183489648..183554570)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (163071003..163136350)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (172374957..172434988)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GNAS is a crucial gene for the beta-cell insulin secretory capacity.
Title: GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells.
Our data revealed a positive correlation between hepatic Gsalpha-cAMP signal axis and fasting blood glucose (FBG) in slight insulin resistance stage of HIgh Sugar High Fat-diet rats and diabetic db/db mice. The current finding thus suggested hepatic Gsalpha-cAMP signal axis plays a central role in regulating of FBG during the developing and development of T2DM.
Title: The Characteristics of Hepatic Gsα-cAMP Axis in HSHF Diet-Fed Obese Insulin Resistance Rats and Genetic Diabetic Mice.
Translocation of Galphas, which shows delayed onset after chronic antidepressant treatment of rats or of C6 glioma cells, tracks with the delayed onset of therapeutic action of antidepressants
Title: Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G Protein, Gαs.
Activated Galpha s translocates from the plasma membrane and, through interaction with tubulin/microtubules in the cytosol, is important for neurite formation, development, and outgrowth.
Title: Activation of microtubule dynamics increases neuronal growth via the nerve growth factor (NGF)- and Gαs-mediated signaling pathways.
Results suggest that the suppression of Dopamine-2 (D2) receptor short (D2S)-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling estradiol (E(2)-activated prolactin (PRL) synthesis and cell proliferation in lactotropes.
Title: Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells.
activated XLalphas and Galphas traffic differently, and this may form the basis for the differences in their cellular actions
Title: Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling.
Data show that the interdomain opening is coupled to receptor binding via the C-terminal helix of G(alpha), the extension of which is a high-affinity receptor binding element.
Title: Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.
Data demonstrated that activated Galpha(s) directly bound to tubulin and cellular microtubules, and fluorescence microscopy showed that cholera toxin-activated Galpha(s) colocalized with microtubules.
Title: Cytosolic G{alpha}s acts as an intracellular messenger to increase microtubule dynamics and promote neurite outgrowth.
Data show that NESP55 positive neurons in the rat superior cervical ganglion project to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid.
Title: Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia.
The differential intracellular expression of NESP55-IR in spinal motoneurons and autonomic neurons suggests that NESP55 may be processed into different secretory granules and may be involved in both constitutive and regulated pathways in these neurons.
Title: Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Gnas (e-PCR), detects polymorphism
- UniSTS:527361

BF389724 (e-PCR)
- UniSTS:245523

UniSTS:496676 (e-PCR)
- UniSTS:496676

Gnas (e-PCR), detects polymorphism
- UniSTS:496676

RH139191 (e-PCR)
- UniSTS:221277

AI230657 (e-PCR)
- UniSTS:249970

RH94424 (e-PCR)
- UniSTS:119672

RH132134 (e-PCR)
- UniSTS:215417

BF398043 (e-PCR)
- UniSTS:246664

Gnas (e-PCR), detects polymorphism
- UniSTS:186518

D3Wox4 (e-PCR)
- UniSTS:517821

BF395949 (e-PCR)
- UniSTS:245456

Gnas (e-PCR), detects polymorphism
- UniSTS:507856

PMC22380P2 (e-PCR)
- UniSTS:272105

RH11717 (e-PCR)
- UniSTS:46841

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein beta-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activator activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activator activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenylate cyclase regulator activity	ISO Inferred from Sequence Orthology more info
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-2 adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-2 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone receptor 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mu-type opioid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables mu-type opioid receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables mu-type opioid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to catecholamine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within energy reserve metabolic process	ISO Inferred from Sequence Orthology more info
involved_in genomic imprinting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within genomic imprinting	ISO Inferred from Sequence Orthology more info
involved_in hair follicle placode formation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic body morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of parathyroid hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of parathyroid hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to parathyroid hormone	IEA Inferred from Electronic Annotation more info
involved_in response to parathyroid hormone	ISO Inferred from Sequence Orthology more info
involved_in response to prostaglandin E	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of chemical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPI-coated Golgi to ER transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ALEX; GNAS; SCG6 (secretogranin VI)

Names: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; GNAS complex locus XLas-like; adenylate cyclase-stimulating G alpha protein; guanine nucleotide binding protein alpha s; guanine nucleotide-binding protein G-s, alpha subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024823.4 → NP_001019994.4 ALEX isoform Alex

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, as compared to variant 3. This variant includes two overlapping open reading frames encoding XLas and Alex, respectively. This RefSeq represents Alex, also known as alexX, which has no similarity to other isoforms encoded by this gene. It interacts with XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells.

Source sequence(s)

BC168156, JAXUCZ010000003, X84047

UniProtKB/TrEMBL

B4F771

Conserved Domains (1) summary

PHA03247
Location:399 → 691

PHA03247; large tegument protein UL36; Provisional
NM_001159653.1 → NP_001153125.1 SCG6 (secretogranin VI) isoform SCG6 precursor

See identical proteins and their annotated locations for NP_001153125.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is maternally expressed. It has alternate 5' exons, as compared to variant 3. Variants 4 and 5 both encode neuroendocrine secretory protein 55 (NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 4 and 5 do not overlap the coding regions used by other transcripts; thus NESP55 has no similarity to isoforms of the G-protein alpha subunit.

Source sequence(s)

AF105254, BC168156, CB770483

UniProtKB/Swiss-Prot

Q792G6

UniProtKB/TrEMBL

A6KL23, G3V916

Conserved Domains (1) summary

pfam06390
Location:1 → 256

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
NM_001159656.1 → NP_001153128.1 SCG6 (secretogranin VI) isoform SCG6 precursor

See identical proteins and their annotated locations for NP_001153128.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) is maternally expressed. It lacks several 3' exons and has alternate 5' and 3' exons, as compared to variant 3. Variants 4 and 5 both encode neuroendocrine secretory protein 55 (NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 4 and 5 do not overlap the coding regions used by other transcripts; thus NESP55 has no similarity to isoforms of the G-protein alpha subunit.

Source sequence(s)

AF105254, AF107845, BC168156, BF394587, CB770483

UniProtKB/Swiss-Prot

Q792G6

UniProtKB/TrEMBL

A6KL23, G3V916

Related

ENSRNOP00000033065.3, ENSRNOT00000035916.7

Conserved Domains (1) summary

pfam06390
Location:1 → 256

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
NM_001359867.2 → NP_001346796.2 GNAS isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an in-frame exon compared to variant 3 and encodes an alternative G-protein alpha subunit (isoform b).

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

B4F771

Related

ENSRNOP00000094944.2, ENSRNOT00000112766.3

Conserved Domains (1) summary

cd00066
Location:41 → 373

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_019132.3 → NP_062005.1 GNAS isoform GNASL

See identical proteins and their annotated locations for NP_062005.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) is biallelically expressed and encodes isoform GNASL, also known as gnas1, a form of the G-protein alpha subunit.

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P63095, Q05087, Q45QM7, Q9Z1R8

UniProtKB/TrEMBL

B0BMW4, B4F771

Related

ENSRNOP00000080642.1, ENSRNOT00000111199.2

Conserved Domains (1) summary

cd00066
Location:41 → 388

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_021845.5 → NP_068617.6 GNAS isoform XLas

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, as compared to variant 3. This variant includes two overlapping open reading frames encoding XLas and Alex, respectively. This RefSeq represents XLas, also known as alpha s XXL, which is a neuroendocrine-specific G-protein alpha subunit; it has a distinct and much longer N-terminus, as compared to isoform GNASL.

Source sequence(s)

BC168156, JAXUCZ010000003, X84047

UniProtKB/Swiss-Prot

Q63803

UniProtKB/TrEMBL

A0A8I6A4D8

Related

ENSRNOP00000088089.1, ENSRNOT00000095590.2

Conserved Domains (3) summary

cd00066
Location:791 → 1138

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:770 → 1141

G_alpha; G protein alpha subunit

pfam12067
Location:81 → 158

Sox_C_TAD; Sox C-terminal transactivation domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

183489648..183554570

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283124.1 → XP_063139194.1 SCG6 (secretogranin VI) isoform X10

UniProtKB/TrEMBL

A6KL23, G3V916
XM_063283123.1 → XP_063139193.1 GNAS isoform X7
XM_039104306.2 → XP_038960234.1 GNAS isoform X8

UniProtKB/TrEMBL

B4F771

Conserved Domains (1) summary

cd00066
Location:5 → 342

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_039104307.2 → XP_038960235.1 GNAS isoform X9

UniProtKB/TrEMBL

B4F771

Conserved Domains (1) summary

cd00066
Location:5 → 341

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_063283121.1 → XP_063139191.1 GNAS isoform X1
XM_039104294.2 → XP_038960222.1 GNAS isoform X2

UniProtKB/Swiss-Prot

Q63803

Conserved Domains (3) summary

cd00066
Location:791 → 1124

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

PHA03247
Location:122 → 560

PHA03247; large tegument protein UL36; Provisional

cd22249
Location:741 → 783

UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins
XM_039104295.2 → XP_038960223.1 GNAS isoform X3

UniProtKB/Swiss-Prot

Q63803

Conserved Domains (3) summary

cd00066
Location:791 → 1123

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

PHA03247
Location:122 → 560

PHA03247; large tegument protein UL36; Provisional

cd22249
Location:741 → 783

UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins
XM_039104300.2 → XP_038960228.1 GNAS isoform X4

UniProtKB/TrEMBL

A0A0G2JWA1

Conserved Domains (1) summary

cd22249
Location:741 → 783

UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins
XM_063283122.1 → XP_063139192.1 GNAS isoform X5
XM_039104304.2 → XP_038960232.1 GNAS isoform X6

UniProtKB/TrEMBL

B4F771

Conserved Domains (1) summary

cd00066
Location:41 → 374

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RNA

XR_010064564.1 RNA Sequence
XR_010064565.1 RNA Sequence

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P63095.1	GenPept	UniProtKB/Swiss-Prot:P63095
Q63803.3	GenPept	UniProtKB/Swiss-Prot:Q63803
Q792G6.1	GenPept	UniProtKB/Swiss-Prot:Q792G6
Q9Z213.1	GenPept	UniProtKB/Swiss-Prot:Q9Z213