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    RRT12 Rrt12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RRT12
    Official Full Name
    Rrt12p
    Primary source
    SGD:S000000641
    Locus tag
    YCR045C
    See related
    AllianceGenome:SGD:S000000641; FungiDB:YCR045C; VEuPathDB:YCR045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OSW3
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in ascospore wall assembly. Located in ascospore wall and nuclear envelope. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RRT12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (208135..209610, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Per1p Neighboring gene mitochondrial 54S ribosomal protein IMG1 Neighboring gene 18S rRNA (guanine1575-N7)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Assay Reveals a Maturation Process during Ascospore Wall Formation. Zhang K, et al. J Fungi (Basel), 2017 Oct 2. PMID 29371570, Free PMC Article
    2. A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly. Suda Y, et al. PLoS One, 2009 Sep 25. PMID 19779569, Free PMC Article
    3. Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae. Hontz RD, et al. Genetics, 2009 May. PMID 19270272, Free PMC Article
    4. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
    5. Environmental and genetic determinants of colony morphology in yeast. Granek JA, et al. PLoS Genet, 2010 Jan 22. PMID 20107600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ascospore wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spore wall IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrt12p
    NP_009974.1
    • Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      208135..209610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178759.1 → NP_009974.1  TPA: Rrt12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009974.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR54, P25381
      UniProtKB/TrEMBL
      B3LUB0, B5VEY6, C7GJU0, C8Z4D5, N1P7N6
      Conserved Domains (1) summary
      cd04077
      Location:130 → 398
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25381.1

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