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    Zfp644 zinc finger protein 644 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305127, updated on 27-Nov-2024

    Summary

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    Symbol
    Zfp644provided by RGD
    Full Name
    zinc finger protein 644provided by RGD
    Primary source
    RGD:1306805
    See related
    EnsemblRapid:ENSRNOG00000002112 AllianceGenome:RGD:1306805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf644; RGD1306805
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ZNF644 (zinc finger protein 644). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 125.7), Brain (RPKM 106.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp644 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (3248350..3324820)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (3105002..3179961)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (4125368..4200332)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120096554 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene keratin-associated protein 10-6-like Neighboring gene basic salivary proline-rich protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 644

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139484.3 → NP_001132956.1  zinc finger protein 644

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KPL0, D4A778
      Related
      ENSRNOP00000002882.7, ENSRNOT00000002882.8
      Conserved Domains (3) summary
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412 → 432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:448 → 470
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      3248350..3324820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599151.3 → XP_017454640.2  zinc finger protein 644 isoform X1

    2. XM_063273040.1 → XP_063129110.1  zinc finger protein 644 isoform X3

      Related
      ENSRNOP00000108635.1, ENSRNOT00000131720.1

    3. XM_063273042.1 → XP_063129112.1  zinc finger protein 644 isoform X6

    4. XM_039091807.2 → XP_038947735.1  zinc finger protein 644 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0C1, D4A778
      Conserved Domains (3) summary
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:423 → 445
      zf-C2H2; Zinc finger, C2H2 type

    5. XM_006250550.3 → XP_006250612.1  zinc finger protein 644 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9B0, D4A778
      Related
      ENSRNOP00000087711.1, ENSRNOT00000097018.2
      Conserved Domains (3) summary
      sd00017
      Location:516 → 536
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:456 → 519
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

    6. XM_063273038.1 → XP_063129108.1  zinc finger protein 644 isoform X1

    7. XM_063273037.1 → XP_063129107.1  zinc finger protein 644 isoform X1

      Related
      ENSRNOP00000085517.2, ENSRNOT00000117440.2

    8. XM_063273043.1 → XP_063129113.1  zinc finger protein 644 isoform X7

      Related
      ENSRNOP00000103033.1, ENSRNOT00000123370.1

    9. XM_006250554.5 → XP_006250616.1  zinc finger protein 644 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0C1, D4A778
      Conserved Domains (3) summary
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:423 → 445
      zf-C2H2; Zinc finger, C2H2 type

    10. XM_063273041.1 → XP_063129111.1  zinc finger protein 644 isoform X5

    11. XM_063273039.1 → XP_063129109.1  zinc finger protein 644 isoform X1

    RNA

    1. XR_010057362.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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