HEM12 uroporphyrinogen decarboxylase HEM12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HEM12
Official Full Name: uroporphyrinogen decarboxylase HEM12
Primary source: SGD:S000002454
Locus tag: YDR047W
See related: AllianceGenome:SGD:S000002454; FungiDB:YDR047W; VEuPathDB:YDR047W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HEM6
Summary: Enables uroporphyrinogen decarboxylase activity. Involved in heme biosynthetic process. Located in cytoplasm and nucleus. Is active in cytosol. Used to study porphyria cutanea tarda. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HEM12 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (551860..552948)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hem12 is monoubiquitinated in vivo by Rsp5
Title: Hem12, an enzyme of heme biosynthesis pathway, is monoubiquitinated by Rsp5 ubiquitin ligase in yeast cells.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables uroporphyrinogen decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uroporphyrinogen decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables uroporphyrinogen decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables uroporphyrinogen decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in porphyrin-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uroporphyrinogen decarboxylase HEM12

NP_010332.3

EC 4.1.1.37

Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

551860..552948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180355.3 → NP_010332.3 TPA: uroporphyrinogen decarboxylase HEM12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010332.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS35, P32347

UniProtKB/TrEMBL

A6ZY14, B3LGM0, B5VFU9, C7GTA2, C8Z4W6, G2WAF3

Conserved Domains (1) summary

cd00717
Location:13 → 358

URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...