Il11 interleukin 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il11provided by RGD
Official Full Name: interleukin 11provided by RGD
Primary source: RGD:621475
See related: EnsemblRapid:ENSRNOG00000017386 AllianceGenome:RGD:621475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il-11
Summary: Predicted to enable cytokine activity; growth factor activity; and interleukin-11 receptor binding activity. Predicted to be involved in interleukin-11-mediated signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to act upstream of or within several processes, including negative regulation of hormone secretion; positive regulation of protein phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and extracellular space. Orthologous to human IL11 (interleukin 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 20.2) and Kidney (RPKM 1.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78098622..78104915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69069829..69076129)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72636959..72643255)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
Title: Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury.
Title: IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury.
Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension.
Title: Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension.
miR-21 is a key regulator of Erk1/2-Stat3 signalling downstream of IL-11 during preconditioning of skeletal myoblasts.
Title: MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.
IL-11 and IL-6 provide protective effects against oxidant-mediated injury in fetal type II cells and IL-11 provides protection in vivo by down-regulation of caspase-mediated cell death
Title: The role of IL-6 and IL-11 in hyperoxic injury in developing lung.
Administration of systemic IL-11 significantly increases the absorption of carbohydrate and amino acid in rats recovering from experimental mesenteric ischemia-reperfusion injury.
Title: Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484899

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH136727 (e-PCR)
- UniSTS:218816

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-11 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-11 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.