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    Emp1 epithelial membrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25314, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Emp1provided by RGD
    Official Full Name
    epithelial membrane protein 1provided by RGD
    Primary source
    RGD:2552
    See related
    EnsemblRapid:ENSRNOG00000008676 AllianceGenome:RGD:2552
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TMP; CL-20; EMP-1; ENP1MR
    Summary
    Predicted to be involved in apoptotic process and bleb assembly. Predicted to be active in plasma membrane. Orthologous to human EMP1 (epithelial membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 353.9), Lung (RPKM 341.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Emp1 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169931537..169964366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (168212901..168233039)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (169161076..169181967)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member B Neighboring gene germ cell associated 1 Neighboring gene phosphatidylethanolamine binding protein 2 Neighboring gene uncharacterized LOC134486686 Neighboring gene small nucleolar RNA SNORA36 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EMP-1 is a junctional protein in a liver stem cell line and in the liver. Lee HS, et al. Biochem Biophys Res Commun, 2005 Sep 9. PMID 16036215
    2. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. Chen Y, et al. Genomics, 1997 Apr 1. PMID 9126480
    3. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. Taylor V, et al. J Biol Chem, 1995 Dec 1. PMID 7499407
    4. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. Wilson HL, et al. J Biol Chem, 2002 Sep 13. PMID 12107182
    5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This report is the first to indicate EMP-1 to be a junctional protein in the liver.
      Title: EMP-1 is a junctional protein in a liver stem cell line and in the liver.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93627

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in bleb assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bleb assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epithelial membrane protein 1
    Names
    tumor-associated membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012843.2 → NP_036975.1  epithelial membrane protein 1

      See identical proteins and their annotated locations for NP_036975.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087031
      UniProtKB/Swiss-Prot
      P54848
      UniProtKB/TrEMBL
      A0A8I5ZRF3, A6IMG6
      Related
      ENSRNOP00000011580.3, ENSRNOT00000011580.8
      Conserved Domains (1) summary
      pfam00822
      Location:1 → 154
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169931537..169964366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285590.1 → XP_063141660.1  epithelial membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P54848
      UniProtKB/TrEMBL
      A6IMG6

    2. XM_063285589.1 → XP_063141659.1  epithelial membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P54848
      UniProtKB/TrEMBL
      A6IMG6
      Related
      ENSRNOP00000081339.2, ENSRNOT00000118837.2

    3. XM_063285588.1 → XP_063141658.1  epithelial membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P54848
      UniProtKB/TrEMBL
      A6IMG6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54848.1 GenPept UniProtKB/Swiss-Prot:P54848

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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