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    Ppfibp2 PPFIA binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppfibp2provided by RGD
    Official Full Name
    PPFIA binding protein 2provided by RGD
    Primary source
    RGD:1565383
    See related
    EnsemblRapid:ENSRNOG00000019667 AllianceGenome:RGD:1565383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in neuromuscular junction development. Is active in presynapse. Orthologous to human PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 91.6), Lung (RPKM 80.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppfibp2 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (170916649..171062096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (161504774..161687339)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (171816231..171969117)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485161 Neighboring gene olfactomedin-like 1 Neighboring gene cytochrome b5 reductase 2 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 like 1 Neighboring gene ovochymase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the central coiled-coil domain from human liprin-β2. Stafford RL, et al. Biochemistry, 2011 May 10. PMID 21462929, Free PMC Article
    2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, et al. Neuron, 2013 Apr 24. PMID 23622064
    3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in presynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    liprin-beta-2
    Names
    PTPRF interacting protein, binding protein 2 (liprin beta 2)
    liprin beta 2
    protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100582.1 → NP_001094052.1  liprin-beta-2

      See identical proteins and their annotated locations for NP_001094052.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I7S0, A6I7S1
      Related
      ENSRNOP00000047694.4, ENSRNOT00000047831.4
      Conserved Domains (6) summary
      cd09563
      Location:555 → 618
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:629 → 691
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:714 → 785
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:555 → 619
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16
      cl23720
      Location:211 → 308
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      170916649..171062096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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