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    Cuedc2 CUE domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294009, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cuedc2provided by RGD
    Official Full Name
    CUE domain containing 2provided by RGD
    Primary source
    RGD:1308096
    See related
    EnsemblRapid:ENSRNOG00000019574 AllianceGenome:RGD:1308096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to act upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Orthologous to human CUEDC2 (CUE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 65.4), Spleen (RPKM 52.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cuedc2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255133479..255142016, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245192057..245200594, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266078107..266087057, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine-rich repeat protein 15 Neighboring gene similar to human chromosome 10 open reading frame 95 Neighboring gene microRNA 146b Neighboring gene major facilitator superfamily domain containing 13A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult. Huang Y, et al. Aging (Albany NY), 2021 Jan 20. PMID 33494071, Free PMC Article
    2. Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer. Chen Y, et al. Cell Rep, 2014 Jun 26. PMID 24882011
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult.
      Title: CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156734

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUE domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079886.1 → NP_001073355.1  CUE domain-containing protein 2

      See identical proteins and their annotated locations for NP_001073355.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127518
      UniProtKB/Swiss-Prot
      A1L131
      UniProtKB/TrEMBL
      A0A8I5ZQ90
      Related
      ENSRNOP00000026609.7, ENSRNOT00000026609.8
      Conserved Domains (1) summary
      cd14367
      Location:126 → 166
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255133479..255142016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287248.1 → XP_063143318.1  CUE domain-containing protein 2 isoform X5

      Related
      ENSRNOP00000080530.2, ENSRNOT00000097448.2

    2. XM_008760410.3 → XP_008758632.1  CUE domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cd14367
      Location:232 → 272
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    3. XM_006231466.4 → XP_006231528.1  CUE domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006231528.1

      UniProtKB/Swiss-Prot
      A1L131
      UniProtKB/TrEMBL
      A0A8I5ZQ90
      Conserved Domains (1) summary
      cd14367
      Location:126 → 166
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    4. XM_006231460.4 → XP_006231522.1  CUE domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006231522.1

      UniProtKB/TrEMBL
      A0A8I5ZQ90, A0A8L2UK80, A6JHM2
      Conserved Domains (1) summary
      cd14367
      Location:144 → 184
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    5. XM_006231458.4 → XP_006231520.1  CUE domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006231520.1

      UniProtKB/TrEMBL
      A0A8I5ZQ90, A0A8L2UK80, A6JHM2
      Conserved Domains (1) summary
      cd14367
      Location:144 → 184
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    6. XM_017589041.2 → XP_017444530.1  CUE domain-containing protein 2 isoform X6

    7. XM_008760411.4 → XP_008758633.3  CUE domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQ90
      Conserved Domains (1) summary
      cd14367
      Location:144 → 184
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    8. XM_006231462.5 → XP_006231524.3  CUE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQ90, A0A8L2UK80, A6JHM2
      Conserved Domains (1) summary
      cd14367
      Location:144 → 184
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    9. XM_008760409.4 → XP_008758631.2  CUE domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A1L131
      UniProtKB/TrEMBL
      A0A8I5ZQ90
      Conserved Domains (1) summary
      cd14367
      Location:126 → 166
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    10. XM_039109080.2 → XP_038965008.1  CUE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQ90, A0A8L2UK80, A6JHM2
      Conserved Domains (1) summary
      cd14367
      Location:144 → 184
      CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

    11. XM_063287257.1 → XP_063143327.1  CUE domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A1L131
      UniProtKB/TrEMBL
      A0A8I5ZQ90
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L131.1 GenPept UniProtKB/Swiss-Prot:A1L131

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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