Camsap1 calmodulin regulated spectrin-associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camsap1provided by RGD
Official Full Name: calmodulin regulated spectrin-associated protein 1provided by RGD
Primary source: RGD:1565022
See related: EnsemblRapid:ENSRNOG00000017883 AllianceGenome:RGD:1565022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565022
Summary: Enables calmodulin binding activity and spectrin binding activity. Involved in neuron projection development. Predicted to be located in microtubule. Predicted to colocalize with microtubule minus-end. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CAMSAP1 (calmodulin regulated spectrin associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 131.2), Testes (RPKM 108.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (29144318..29206382, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8746176..8806067, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (3373971..3434027, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.
Title: MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.
CAMSAP-conserved region represents a functional region of CAMSAP1, which links spectrin-binding to neurite outgrowth
Title: A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed
enables spectrin binding	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with microtubule minus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule minus-end	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calmodulin-regulated spectrin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168549.2 → NP_001162021.1 calmodulin-regulated spectrin-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_001162021.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D3Z8E6

UniProtKB/TrEMBL

A0A0G2K5T1

Related

ENSRNOP00000024163.6, ENSRNOT00000024163.9

Conserved Domains (5) summary

smart01051
Location:1465 → 1593

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:248 → 331

CAMSAP_CH; CAMSAP CH domain

pfam15346
Location:1278 → 1355

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:880 → 938

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl21478
Location:1276 → 1357

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001415687.1 → NP_001402616.1 calmodulin-regulated spectrin-associated protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K5T1, A0A8I5ZW13

Related

ENSRNOP00000081912.1, ENSRNOT00000099628.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

29144318..29206382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233672.5 → XP_006233734.1 calmodulin-regulated spectrin-associated protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K5T1

Conserved Domains (5) summary

smart01051
Location:1455 → 1583

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:239 → 322

CAMSAP_CH; CAMSAP CH domain

pfam15346
Location:1269 → 1346

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:871 → 929

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl21478
Location:1267 → 1348

ATP-synt_B; ATP synthase B/B' CF(0)
XM_006233674.5 → XP_006233736.1 calmodulin-regulated spectrin-associated protein 1 isoform X4

UniProtKB/TrEMBL

A0A0G2K5T1

Conserved Domains (5) summary

smart01051
Location:1444 → 1572

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:228 → 311

CAMSAP_CH; CAMSAP CH domain

pfam15346
Location:1258 → 1335

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:860 → 918

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl21478
Location:1256 → 1337

ATP-synt_B; ATP synthase B/B' CF(0)
XM_063283467.1 → XP_063139537.1 calmodulin-regulated spectrin-associated protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K5T1, A0A8I5ZW13
XM_006233675.5 → XP_006233737.1 calmodulin-regulated spectrin-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K5T1, A0A8I6GHB0

Related

ENSRNOP00000088653.1, ENSRNOT00000101799.2

Conserved Domains (5) summary

smart01051
Location:1456 → 1584

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:239 → 322

CAMSAP_CH; CAMSAP CH domain

pfam15346
Location:1269 → 1346

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:871 → 929

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl21478
Location:1267 → 1348

ATP-synt_B; ATP synthase B/B' CF(0)
XM_039104722.2 → XP_038960650.1 calmodulin-regulated spectrin-associated protein 1 isoform X5

UniProtKB/TrEMBL

A0A0G2K5T1

Conserved Domains (5) summary

PTZ00121
Location:1059 → 1231

PTZ00121; MAEBL; Provisional

pfam11971
Location:119 → 202

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1337 → 1455

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam15346
Location:1149 → 1226

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:751 → 809

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_039104723.2 → XP_038960651.1 calmodulin-regulated spectrin-associated protein 1 isoform X6

UniProtKB/TrEMBL

A0A0G2K5T1

Conserved Domains (5) summary

PTZ00121
Location:891 → 1063

PTZ00121; MAEBL; Provisional

smart01051
Location:1168 → 1296

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam15346
Location:981 → 1058

ARGLU; Arginine and glutamate-rich 1

pfam17095
Location:583 → 641

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

cl00030
Location:1 → 34

CH_SF; calponin homology (CH) domain superfamily