Bcat2 branched chain amino acid transaminase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcat2provided by RGD
Official Full Name: branched chain amino acid transaminase 2provided by RGD
Primary source: RGD:68948
See related: EnsemblRapid:ENSRNOG00000020956 AllianceGenome:RGD:68948
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BCT2; Bcatm; mBcat
Summary: Enables branched-chain-amino-acid transaminase activity. Involved in L-leucine biosynthetic process; isoleucine catabolic process; and lactation. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 209.9), Kidney (RPKM 172.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105175157..105196474)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96040407..96060008)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101553900..101572103)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation.
Title: Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation.
The effect of KIC on insulin-stimulated glucose transport was abrogated in cells depleted of branched-chain aminotransferase 2 (BCAT2).
Title: Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner.
GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate.
Title: Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-isoleucine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-isoleucine-2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-leucine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-leucine-2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-valine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-valine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-valine-2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables branched-chain-amino-acid transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain-amino-acid transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables branched-chain-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-amino-acid transaminase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-leucine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branched-chain amino acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branched-chain amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in branched-chain amino acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in isoleucine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isoleucine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within isoleucine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone levels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hormone levels	ISO Inferred from Sequence Orthology more info
involved_in valine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within valine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: branched-chain-amino-acid aminotransferase, mitochondrial

Names: BCAT(m); branched chain amino acid transaminase 2, mitochondrial; branched chain aminotransferase 2, mitochondrial; heart branched chain aminotransferase precursor encoding mitochondrial protein

NP_071795.2

EC 2.6.1.42

XP_006229211.1

EC 2.6.1.42

XP_017445146.1

EC 2.6.1.42

XP_038945432.1

EC 2.6.1.42

XP_063128813.1

EC 2.6.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022400.2 → NP_071795.2 branched-chain-amino-acid aminotransferase, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35854

UniProtKB/TrEMBL

A6JB55, G3V8U8

Related

ENSRNOP00000095006.1, ENSRNOT00000095787.2

Conserved Domains (1) summary

cd01557
Location:88 → 383

BCAT_beta_family; Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105175157..105196474

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089504.2 → XP_038945432.1 branched-chain-amino-acid aminotransferase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

O35854

Related

ENSRNOP00000028474.4, ENSRNOT00000028474.7

Conserved Domains (1) summary

cd01557
Location:103 → 398

BCAT_beta_family; Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The ...
XM_006229149.3 → XP_006229211.1 branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006229211.1

UniProtKB/Swiss-Prot

O35854

UniProtKB/TrEMBL

A6JB56

Conserved Domains (2) summary

PRK13357
Location:1 → 329

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:24 → 319

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
XM_017589657.3 → XP_017445146.1 branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

UniProtKB/Swiss-Prot

O35854

UniProtKB/TrEMBL

A6JB56

Related

ENSRNOP00000099982.1, ENSRNOT00000168131.1

Conserved Domains (2) summary

PRK13357
Location:1 → 329

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:24 → 319

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
XM_063272743.1 → XP_063128813.1 branched-chain-amino-acid aminotransferase, mitochondrial isoform X3