F11r F11 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F11rprovided by RGD
Official Full Name: F11 receptorprovided by RGD
Primary source: RGD:621842
See related: EnsemblRapid:ENSRNOG00000004414 AllianceGenome:RGD:621842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Jam1
Summary: Predicted to enable PDZ domain binding activity; integrin binding activity; and protein homodimerization activity. Involved in cell differentiation and positive regulation of blood pressure. Located in slit diaphragm. Biomarker of hypertension; peptic esophagitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 1622.3), Lung (RPKM 474.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86406229..86429819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83873797..83897388)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89826272..89850151)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings support a key role of JAM-A in promoting tight junction homeostasis and lung barrier function by coordinating interactions among claudins, the tight junction scaffold, and the cytoskeleton.
Title: Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function.
JAM-A promotes proliferation and inhibits apoptosis of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression.
Title: Junctional adhesion molecule-A promotes proliferation and inhibits apoptosis of gastric cancer.
Suggest a prognostic and possibly a pathogenic role of JAM-A in arterial hypertension.
Title: Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.
When junctional adhesion molecule-1 (JAM-1) is expressed in the nucleus tractus solitarii, it raises arterial pressure, suggesting a novel prohypertensive role for this protein within the brain stem.
Title: Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem.
There was a significant down-regulation in the expression of occludin abd JAM-1 after exposure to microwave radiation.
Title: [Microwave radiation decreases the expressions of occludin and JAM-1 in rats].
Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown.
Title: Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

F11r (e-PCR), detects polymorphism
- UniSTS:516175

F11r (e-PCR), detects polymorphism
- UniSTS:525484

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in memory T cell extravasation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to bicellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junctional adhesion molecule A

Names: JAM-1; JAM-A; junctional adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053796.1 → NP_446248.1 junctional adhesion molecule A precursor

See identical proteins and their annotated locations for NP_446248.1

Status: PROVISIONAL

Source sequence(s)

AF276998

UniProtKB/Swiss-Prot

Q9JHY1

UniProtKB/TrEMBL

A0A8L2Q2H4

Related

ENSRNOP00000006141.4, ENSRNOT00000006141.7

Conserved Domains (3) summary

smart00410
Location:37 → 127

IG_like; Immunoglobulin like

pfam07686
Location:33 → 128

V-set; Immunoglobulin V-set domain

cl11960
Location:139 → 229

Ig; Immunoglobulin domain