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    Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r5eprovided by RGD
    Official Full Name
    protein phosphatase 2 regulatory subunit B', epsilonprovided by RGD
    Primary source
    RGD:1305657
    See related
    EnsemblRapid:ENSRNOG00000005045 AllianceGenome:RGD:1305657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Biomarker of transient cerebral ischemia. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 82.0), Brain (RPKM 78.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r5e in Genome Data Viewer
    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (99904569..100053672, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (94168846..94317872, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (98417974..98567016, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ras homolog family member J Neighboring gene glycoprotein hormone subunit beta 5 Neighboring gene uncharacterized LOC120093261 Neighboring gene uncharacterized LOC120103554 Neighboring gene WD repeat domain 89

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats. Xu H, et al. Rejuvenation Res, 2019 Dec. PMID 30712471
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106740.1 → NP_001100210.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 2

      See identical proteins and their annotated locations for NP_001100210.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A0A0G2JTA1, A6HC79, D3ZHI9
      Related
      ENSRNOP00000006755.5, ENSRNOT00000006755.8
      Conserved Domains (2) summary
      PLN00122
      Location:321 → 397
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:55 → 397
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001434268.1 → NP_001421197.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JTA1, A0A8I5ZMG6

    3. NM_001434269.1 → NP_001421198.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JTA1, A0A8I5ZMG6

    RNA

    1. NR_197772.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      99904569..100053672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240222.4 → XP_006240284.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

      Related
      ENSRNOP00000079138.1, ENSRNOT00000094518.2
      Conserved Domains (2) summary
      pfam01603
      Location:55 → 435
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:2 → 67
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. XM_006240223.5 → XP_006240285.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

      Conserved Domains (2) summary
      pfam01603
      Location:55 → 435
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:2 → 67
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_006240224.5 → XP_006240286.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTA1
      Related
      ENSRNOP00000099221.1, ENSRNOT00000173031.1
      Conserved Domains (2) summary
      PLN00122
      Location:335 → 411
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:31 → 411
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. XM_039112010.2 → XP_038967938.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3

      UniProtKB/TrEMBL
      A0A0G2JTA1, A0A8I6A9W8
      Related
      ENSRNOP00000089462.1, ENSRNOT00000105642.2
      Conserved Domains (1) summary
      pfam01603
      Location:23 → 403
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein Strain
    Heading Accession and Version

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