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    Fbf1 Fas binding factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbf1provided by RGD
    Official Full Name
    Fas binding factor 1provided by RGD
    Primary source
    RGD:1310662
    See related
    EnsemblRapid:ENSRNOG00000008577 AllianceGenome:RGD:1310662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in apical junction assembly; cilium assembly; and establishment of epithelial cell polarity. Predicted to be located in apical junction complex and cytoskeleton. Predicted to be part of ciliary transition fiber. Predicted to be active in centriole and ciliary basal body. Orthologous to human FBF1 (Fas binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 72.6), Adrenal (RPKM 62.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbf1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101874661..101900497, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101375769..101401624, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104692791..104718630, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093105 Neighboring gene tripartite motif-containing 65 Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene acyl-CoA oxidase 1 Neighboring gene uncharacterized LOC134480905 Neighboring gene TEN1 subunit of CST complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The keratin-binding protein Albatross regulates polarization of epithelial cells. Sugimoto M, et al. J Cell Biol, 2008 Oct 6. PMID 18838552, Free PMC Article
    2. Centriole distal appendages promote membrane docking, leading to cilia initiation. Tanos BE, et al. Genes Dev, 2013 Jan 15. PMID 23348840, Free PMC Article
    3. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apical junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fas binding factor 1; fas-binding factor 1
    Names
    Fas (TNFRSF6) binding factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430164.1 → NP_001417093.1  Fas binding factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    2. NM_001430165.1 → NP_001417094.1  Fas binding factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AVT6

    3. NM_001430166.1 → NP_001417095.1  Fas binding factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    4. NM_001430167.1 → NP_001417096.1  Fas binding factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    5. NM_001430168.1 → NP_001417097.1  Fas binding factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    6. NM_001430169.1 → NP_001417098.1  Fas binding factor 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    7. NM_001430170.1 → NP_001417099.1  Fas binding factor 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    8. NM_001430171.1 → NP_001417100.1  Fas binding factor 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101874661..101900497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270177.1 → XP_063126247.1  fas-binding factor 1 isoform X5

    2. XM_063270175.1 → XP_063126245.1  fas-binding factor 1 isoform X2

    3. XM_063270187.1 → XP_063126257.1  fas-binding factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AQV1

    4. XM_063270178.1 → XP_063126248.1  fas-binding factor 1 isoform X6

    5. XM_006247761.5 → XP_006247823.1  fas-binding factor 1 isoform X3

      See identical proteins and their annotated locations for XP_006247823.1

      Conserved Domains (3) summary
      pfam13863
      Location:640 → 751
      DUF4200; Domain of unknown function (DUF4200)
      pfam14988
      Location:803 → 994
      DUF4515; Domain of unknown function (DUF4515)
      cl23720
      Location:803 → 912
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    6. XM_063270186.1 → XP_063126256.1  fas-binding factor 1 isoform X11

    7. XM_006247760.5 → XP_006247822.1  fas-binding factor 1 isoform X1

      Related
      ENSRNOP00000092550.2, ENSRNOT00000102155.2
      Conserved Domains (3) summary
      pfam13863
      Location:641 → 752
      DUF4200; Domain of unknown function (DUF4200)
      pfam14988
      Location:804 → 995
      DUF4515; Domain of unknown function (DUF4515)
      cl23720
      Location:804 → 913
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    8. XM_063270180.1 → XP_063126250.1  fas-binding factor 1 isoform X7

      UniProtKB/TrEMBL
      F1LSG3
      Related
      ENSRNOP00000011560.7, ENSRNOT00000011560.10

    9. XM_063270179.1 → XP_063126249.1  fas-binding factor 1 isoform X7

      UniProtKB/TrEMBL
      F1LSG3

    10. XM_063270176.1 → XP_063126246.1  fas-binding factor 1 isoform X4

    11. XM_063270189.1 → XP_063126259.1  fas-binding factor 1 isoform X14

    12. XM_063270185.1 → XP_063126255.1  fas-binding factor 1 isoform X10

    13. XM_063270181.1 → XP_063126251.1  fas-binding factor 1 isoform X7

      UniProtKB/TrEMBL
      F1LSG3
      Related
      ENSRNOP00000099785.1, ENSRNOT00000151074.1

    14. XM_063270184.1 → XP_063126254.1  fas-binding factor 1 isoform X9

    15. XM_063270188.1 → XP_063126258.1  fas-binding factor 1 isoform X13

      Related
      ENSRNOP00000096585.2, ENSRNOT00000116692.2

    16. XM_063270191.1 → XP_063126261.1  fas-binding factor 1 isoform X14

    17. XM_063270182.1 → XP_063126252.1  fas-binding factor 1 isoform X7

      UniProtKB/TrEMBL
      F1LSG3

    18. XM_063270190.1 → XP_063126260.1  fas-binding factor 1 isoform X14

    19. XM_063270183.1 → XP_063126253.1  fas-binding factor 1 isoform X8

    20. XM_063270192.1 → XP_063126262.1  fas-binding factor 1 isoform X15

    RNA

    1. XR_010055882.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105854.1: Suppressed sequence

      Description
      NM_001105854.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: FBF1 (GeneID:770159).
    Nucleotide Protein Strain
    Heading Accession and Version

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