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    Car12 carbonic anhydrase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Car12provided by RGD
    Official Full Name
    carbonic anhydrase 12provided by RGD
    Primary source
    RGD:1306612
    See related
    EnsemblRapid:ENSRNOG00000017766 AllianceGenome:RGD:1306612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca12
    Summary
    Predicted to enable carbonate dehydratase activity. Involved in estrous cycle. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2722.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Car12 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76169723..76225465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67274739..67330428)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72405770..72461425)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094375 Neighboring gene uncharacterized LOC134480068 Neighboring gene uncharacterized LOC120094191 Neighboring gene aph-1 homolog B, gamma secretase subunit like 2 Neighboring gene aph-1 homolog B, gamma secretase subunit like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrative Proteo-Genomic Analysis for Recurrent Survival Prognosis in Colon Adenocarcinoma. Ai F, et al. Front Oncol, 2022. PMID 35847888, Free PMC Article
    2. The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations. Zeng J, et al. Oxid Med Cell Longev, 2023. PMID 36846718, Free PMC Article
    3. Prognostic value of carbonic anhydrase XII (CA XII) overexpression in hepatocellular carcinoma. Gu XF, et al. Int J Clin Exp Pathol, 2019. PMID 31934040, Free PMC Article
    4. Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus. Halmi P, et al. Neurochem Int, 2006 Jan. PMID 16271802
    5. An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. von Neubeck B, et al. Int J Cancer, 2018 Oct 15. PMID 29786141

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
      Title: The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
    2. binding of HIF-1alpha to select hypoxia-responsive elements on CA9/12 promoters, was observed.
      Title: Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrous cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 12
    Names
    carbonic anyhydrase 12
    membrane-bound carbonic anhydrase 12
    NP_001074225.1
    XP_006243373.1
    XP_063121841.1
    XP_063121842.1
    XP_063121843.1
    XP_063121844.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080756.2 → NP_001074225.1  carbonic anhydrase 12 precursor

      See identical proteins and their annotated locations for NP_001074225.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A5P9, A2IBE2
      Conserved Domains (1) summary
      cl00012
      Location:39 → 290
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76169723..76225465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265771.1 → XP_063121841.1  carbonic anhydrase 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5P9, F7FAJ9
      Related
      ENSRNOP00000023952.6, ENSRNOT00000023952.8

    2. XM_006243311.5 → XP_006243373.1  carbonic anhydrase 12 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5P9, A0A8I6AH35
      Related
      ENSRNOP00000091938.1, ENSRNOT00000105264.2
      Conserved Domains (1) summary
      cl00012
      Location:39 → 290
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. XM_063265772.1 → XP_063121842.1  carbonic anhydrase 12 isoform X3

      UniProtKB/TrEMBL
      A6J5I5

    4. XM_063265774.1 → XP_063121844.1  carbonic anhydrase 12 isoform X4

      UniProtKB/TrEMBL
      A6J5I4, A6J5I5

    5. XM_063265773.1 → XP_063121843.1  carbonic anhydrase 12 isoform X3

      UniProtKB/TrEMBL
      A6J5I5
    Nucleotide Protein Strain
    Heading Accession and Version

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