Zfp423 zinc finger protein 423 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp423provided by RGD
Official Full Name: zinc finger protein 423provided by RGD
Primary source: RGD:621664
See related: EnsemblRapid:ENSRNOG00000014658 AllianceGenome:RGD:621664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Roaz; Znf423
Summary: Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 52.6), Brain (RPKM 50.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (35282149..35580775)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (19111213..19407373)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (20147201..20405999)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046515 (e-PCR)
- UniSTS:111377

Zfp423 (e-PCR), detects polymorphism
- UniSTS:474696

D19Rat39 (e-PCR), detects polymorphism
- UniSTS:226987

D19Rat51 (e-PCR), detects polymorphism
- UniSTS:226990

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell precursor proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cilium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 423

Names: Olf-1/EBF associated Zn finger protein Roaz; olf1/EBF-associated zinc finger protein; smad- and Olf-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393718.1 → NP_001380647.1 zinc finger protein 423

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O08961, Q63681

UniProtKB/TrEMBL

A0A8I5ZY81

Related

ENSRNOP00000085196.2, ENSRNOT00000101895.2

Conserved Domains (2) summary

COG5048
Location:202 → 603

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:148 → 168

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

35282149..35580775

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278334.1 → XP_063134404.1 zinc finger protein 423 isoform X3

UniProtKB/TrEMBL

A0A8I6A1R1, A6KDA7, F1LR04

Related

ENSRNOP00000107589.1, ENSRNOT00000153975.1
XM_063278328.1 → XP_063134398.1 zinc finger protein 423 isoform X1

UniProtKB/Swiss-Prot

O08961, Q63681
XM_063278329.1 → XP_063134399.1 zinc finger protein 423 isoform X2

UniProtKB/TrEMBL

F1LR04
XM_063278333.1 → XP_063134403.1 zinc finger protein 423 isoform X3

UniProtKB/TrEMBL

A0A8I6A1R1, A6KDA7, F1LR04
XM_063278330.1 → XP_063134400.1 zinc finger protein 423 isoform X2

UniProtKB/TrEMBL

F1LR04
XM_063278332.1 → XP_063134402.1 zinc finger protein 423 isoform X2

UniProtKB/TrEMBL

F1LR04
XM_063278331.1 → XP_063134401.1 zinc finger protein 423 isoform X2

UniProtKB/TrEMBL

F1LR04

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053583.2: Suppressed sequence

Description

NM_053583.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.