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    Filip1l filamin A interacting protein 1-like [ Mus musculus (house mouse) ]

    Gene ID: 78749, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Filip1lprovided by MGI
    Official Full Name
    filamin A interacting protein 1-likeprovided by MGI
    Primary source
    MGI:MGI:1925999
    See related
    Ensembl:ENSMUSG00000043336 AllianceGenome:MGI:1925999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Doc1; 4631422O05Rik
    Summary
    Acts upstream of or within several processes, including hindgut development; proteasomal protein catabolic process; and protein secretion. Is active in centrosome. Is expressed in pectoral girdle and thoracic body wall musculature. Orthologous to human FILIP1L (filamin A interacting protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 18.6), limb E14.5 (RPKM 7.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Filip1l in Genome Data Viewer
    Location:
    16 C1.1; 16 34.22 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (57173376..57393167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57353277..57572804)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41082 Neighboring gene STARR-seq mESC enhancer starr_41083 Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1 Neighboring gene STARR-seq mESC enhancer starr_41085 Neighboring gene STARR-positive B cell enhancer ABC_E11618 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_41086 Neighboring gene STARR-seq mESC enhancer starr_41087 Neighboring gene STARR-positive B cell enhancer ABC_E7469 Neighboring gene STARR-seq mESC enhancer starr_41088 Neighboring gene STARR-positive B cell enhancer ABC_E10913 Neighboring gene predicted gene, 53930 Neighboring gene STARR-positive B cell enhancer ABC_E4181 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:57606921-57607108 Neighboring gene microRNA 1970b Neighboring gene collagen, type VIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:57669432-57669732 Neighboring gene STARR-seq mESC enhancer starr_41090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis. Kwon M, et al. Cancer Res Commun, 2022 Oct. PMID 36860703, Free PMC Article
    2. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Kwon M, et al. Cancer Res, 2021 Nov 1. PMID 34417201, Free PMC Article
    3. Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex. Yagi H, et al. Neurosci Lett, 2016 Jan 26. PMID 26655467
    4. Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis. Kang X, et al. Cell Stem Cell, 2024 Feb 1. PMID 38232727
    5. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). Revert-Ros F, et al. J Biol Chem, 2011 Oct 7. PMID 21832087, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
      Title: Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
    2. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
      Title: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
    3. GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein
      Title: Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hindgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in centrosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    filamin A-interacting protein 1-like
    Names
    downregulated in ovarian cancer 1-like
    protein down-regulated in ovarian cancer 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040397.5 → NP_001035487.2  filamin A-interacting protein 1-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC144776, CT025521, CT030226
      Consensus CDS
      CCDS37366.2
      UniProtKB/Swiss-Prot
      B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0
      UniProtKB/TrEMBL
      E0CYH7
      Related
      ENSMUSP00000124179.2, ENSMUST00000159816.8
      Conserved Domains (3) summary
      COG0419
      Location:85 → 678
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:539 → 842
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09727
      Location:64 → 246
      CortBP2; Cortactin-binding protein-2

    2. NM_001177871.1 → NP_001171342.1  filamin A-interacting protein 1-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC144776, AK019472
      Consensus CDS
      CCDS49877.1
      UniProtKB/TrEMBL
      E0CYM1
      Related
      ENSMUSP00000124069.2, ENSMUST00000159414.2
      Conserved Domains (5) summary
      COG1340
      Location:87 → 360
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam00901
      Location:189 → 302
      Orbi_VP5; Orbivirus outer capsid protein VP5
      pfam06009
      Location:53 → 139
      Laminin_II; Laminin Domain II
      pfam17061
      Location:668 → 890
      PARM; PARM
      cl03075
      Location:380 → 431
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      57173376..57393167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249333.2 → XP_030105193.1  filamin A-interacting protein 1-like isoform X1

      UniProtKB/Swiss-Prot
      B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0
      Conserved Domains (3) summary
      COG1196
      Location:138 → 502
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:4 → 220
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam17061
      Location:722 → 944
      PARM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6L0.2 GenPept UniProtKB/Swiss-Prot:Q6P6L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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