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    pinta prolonged depolarization afterpotential (PDA) is not apparent [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pintaprovided by FlyBase
    Official Full Name
    prolonged depolarization afterpotential (PDA) is not apparentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038966
    Locus tag
    Dmel_CG13848
    See related
    AllianceGenome:FB:FBgn0038966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13848; CT33362; Dmel\CG13848; Pinta; PINTA; sec14
    Summary
    Enables retinoid binding activity. Involved in phototransduction and rhodopsin biosynthetic process. Is expressed in adult head; embryonic/larval garland cell; lch5 scolopidial dendritic cap cell; scolopale cell; and scolopidial dendritic cap cell. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pinta in Genome Data Viewer
    Location:
    94A12-94A13; 3-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22423316..22424929, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18249038..18250651, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nop56 Neighboring gene mob as tumor suppressor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors. Voolstra O, et al. J Biol Chem, 2010 Jan 15. PMID 19889630, Free PMC Article
    2. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Lai ZC, et al. Cell, 2005 Mar 11. PMID 15766530
    3. Both upstream and downstream intergenic regions are critical for the mob as tumor suppressor gene activity in Drosophila. Yang Y, et al. FEBS Lett, 2008 May 28. PMID 18472003
    4. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. Wang T, et al. J Neurosci, 2005 May 25. PMID 15917458, Free PMC Article
    5. Chromophore-Independent Roles of Opsin Apoproteins in Drosophila Mechanoreceptors. Katana R, et al. Curr Biol, 2019 Sep 9. PMID 31447373

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein
      Title: Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolonged depolarization afterpotential (PDA) is not apparent
    Names
    CG13848-PA
    CG13848-PB
    Lyso-PA acyltransferase
    pinta-PA
    pinta-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22423316..22424929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300537.1 → NP_001287466.1  prolonged depolarization afterpotential (PDA) is not apparent, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VD09
      Conserved Domains (1) summary
      cd00170
      Location:87 → 240
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_142785.2 → NP_651042.1  prolonged depolarization afterpotential (PDA) is not apparent, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VD09
      Related
      FBpp0083690
      Conserved Domains (1) summary
      cd00170
      Location:87 → 240
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD09.1 Q9VD09

    Gene LinkOut

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