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    Decay Death executioner caspase related to Apopain/Yama [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42008, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Decayprovided by FlyBase
    Official Full Name
    Death executioner caspase related to Apopain/Yamaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028381
    Locus tag
    Dmel_CG14902
    See related
    AllianceGenome:FB:FBgn0028381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cas3; Cas3; CAS3; Casp-3; Casp3; Caspae-3; caspase 3; caspase-3; Caspase-3; CC-3; CC3; CG14902; decay; DECAY; Dmel\CG14902; Drosophila executioner caspase related to Apopain/Yama
    Summary
    Enables cysteine-type endopeptidase activity. Involved in apoptotic process. Located in cytoplasm. Is expressed in several structures, including adult head; egg chamber; female germline cell; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to human CASP3 (caspase 3) and CASP7 (caspase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Decay in Genome Data Viewer
    Location:
    89B18-89B18; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16499058..16501050, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12324780..12326772, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cadherin 89D Neighboring gene Gustatory receptor 89a Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46030 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve. Podratz JL, et al. Neurobiol Dis, 2017 Jan. PMID 27765583, Free PMC Article
    2. Melatonin Mitigates Rotenone-Induced Oxidative Stress and Mitochondrial Dysfunction in the Drosophila melanogaster Model of Parkinson's Disease-like Symptoms. Rasheed MZ, et al. ACS Omega, 2023 Feb 28. PMID 36872990, Free PMC Article
    3. Drosophila RecQ5 is involved in proper progression of early spermatogenesis. Sakurai H, et al. Biochem Biophys Res Commun, 2014 Oct 3. PMID 25245292
    4. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7. Dorstyn L, et al. J Biol Chem, 1999 Oct 22. PMID 10521468
    5. A gum Arabic assisted sustainable drug delivery system for adult Drosophila. Liang Q, et al. Biol Open, 2020 Jun 14. PMID 32487516, Free PMC Article

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in larval midgut histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death executioner caspase related to Apopain/Yama
    Names
    CG14902-PA
    Caspase-3
    Caspase3
    Decay-PA
    caspase 3
    caspase-3 protein
    cleaved caspase 3
    decay
    NP_477462.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16499058..16501050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058114.4 → NP_477462.1  death executioner caspase related to Apopain/Yama [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHF9, Q9VET9
      Related
      FBpp0082755
      Conserved Domains (1) summary
      cd00032
      Location:54 → 302
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHF9 Q9NHF9
    Q9VET9 Q9VET9

    Gene LinkOut

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