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    CanA-14F Calcineurin A at 14F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674098, updated on 9-Dec-2024

    Summary

    Official Symbol
    CanA-14Fprovided by FlyBase
    Official Full Name
    Calcineurin A at 14Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267912
    Locus tag
    Dmel_CG9819
    See related
    AllianceGenome:FB:FBgn0267912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CaN; canA-14F; CaNA-14F; CanA14F; CG9819; CnnA14D; CnnA14D(I); D27; DmCanA-14F; Dmel\CG9819; MRE12; PP2B; PpD27
    Summary
    Enables calmodulin-dependent protein phosphatase activity. Involved in sleep. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult brain; adult optic lobe; and retina. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CanA-14F in Genome Data Viewer
    Location:
    14E3-14F1; 1-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16560684..16587172, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16454717..16481205, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin-related protein 2 Neighboring gene Protein phosphatase 2B at 14D Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding  
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity PubMed 
    enables protein binding PubMed 
    enables protein serine/threonine phosphatase activity PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling  
    involved_in calcineurin-mediated signaling  
    involved_in sleep PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex  
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    calcineurin A at 14F
    Names
    CG9819-PA
    CG9819-PB
    CG9819-PC
    CG9819-PD
    CanA-14F-PA
    CanA-14F-PB
    CanA-14F-PC
    CanA-14F-PD
    calcineurin
    mRNA-like ncRNA in embryogenesis 12
    protein phosphatase D27
    protein phosphatase from PCR fragment D27
    NP_001245717.1
    NP_001259622.1
    NP_727985.2
    NP_727986.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16560684..16587172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258788.2 → NP_001245717.1  calcineurin A at 14F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_167524.3 → NP_727986.2  calcineurin A at 14F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727986.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain
    3. NM_001272693.2 → NP_001259622.1  calcineurin A at 14F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain
    4. NM_167523.3 → NP_727985.2  calcineurin A at 14F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727985.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain
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