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    CG8046 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8046provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033388
    Locus tag
    Dmel_CG8046
    See related
    AllianceGenome:FB:FBgn0033388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8046; SLC46
    Summary
    Enables peptidoglycan transmembrane transporter activity. Involved in peptidoglycan transport; positive regulation of antimicrobial humoral response; and positive regulation of peptidoglycan recognition protein signaling pathway. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8046 in Genome Data Viewer
    Location:
    45B1-45B1; 2-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9162037..9164967, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5049542..5052472, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44283 Neighboring gene Rad51 recombinase D Neighboring gene uncharacterized protein Neighboring gene Receptor mediated endocytosis 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. Paik D, et al. J Immunol, 2017 Jul 1. PMID 28539433, Free PMC Article
    2. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Hansen KD, et al. PLoS Genet, 2009 Jun. PMID 19543372, Free PMC Article
    3. Iap2 is required for a sustained response in the Drosophila Imd pathway. Valanne S, et al. Dev Comp Immunol, 2007. PMID 17343912
    4. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018
    5. Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila. Vesala L, et al. BMC Biol, 2024 Mar 13. PMID 38475850, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidoglycan transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidoglycan transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8046-PA
    CG8046-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9162037..9164967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136621.4 → NP_610465.2  uncharacterized protein Dmel_CG8046, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610465.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R72
      Related
      FBpp0087702
      Conserved Domains (2) summary
      cd06174
      Location:10 → 372
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:7 → 336
      MFS_1; Major Facilitator Superfamily

    2. NM_165657.3 → NP_724761.1  uncharacterized protein Dmel_CG8046, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7R6, A1Z7R7
      UniProtKB/TrEMBL
      Q86P46
      Related
      FBpp0087701
      Conserved Domains (2) summary
      cd06174
      Location:141 → 503
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:138 → 467
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7R6 A1Z7R6
    A1Z7R7 A1Z7R7
    Q86P46 Q86P46
    Q95R72 Q95R72

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