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    CG7236 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7236provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031730
    Locus tag
    Dmel_CG7236
    See related
    AllianceGenome:FB:FBgn0031730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC018104; CG7236/Cdk1l; Dmel\CG7236; KKIALRE
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human CDKL1 (cyclin dependent kinase like 1) and CDKL4 (cyclin dependent kinase like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7236 in Genome Data Viewer
    Location:
    25F3-25F3; 2-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5706374..5713791)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5706374..5713791)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44819 Neighboring gene long non-coding RNA:CR44820 Neighboring gene antisense RNA:CR44818 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. Liu T, et al. Genome Biol, 2009. PMID 19265526, Free PMC Article
    2. Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Wei JY, et al. Sci Rep, 2022 Jan 7. PMID 34997175, Free PMC Article
    3. Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. Yin Z, et al. BMC Bioinformatics, 2008 Jun 5. PMID 18534020, Free PMC Article
    4. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. Liu J, et al. Mol Biol Evol, 2000 Jul. PMID 10889219
    5. Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster. Noble GP, et al. G3 (Bethesda), 2016 Oct 13. PMID 27489208, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7236-PB
    CG7236-PC
    CG7236-PD
    CG7236-PE
    NP_001188702.1
    NP_001285634.1
    NP_001285635.1
    NP_608950.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5706374..5713791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298706.1 → NP_001285635.1  uncharacterized protein Dmel_CG7236, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD86
      Conserved Domains (1) summary
      cd07847
      Location:31 → 318
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. NM_135106.4 → NP_608950.3  uncharacterized protein Dmel_CG7236, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608950.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMN3
      Conserved Domains (2) summary
      cd07847
      Location:48 → 335
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
      pfam00069
      Location:50 → 335
      Pkinase; Protein kinase domain

    3. NM_001298705.1 → NP_001285634.1  uncharacterized protein Dmel_CG7236, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J708
      Conserved Domains (1) summary
      cd07847
      Location:22 → 309
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    4. NM_001201773.2 → NP_001188702.1  uncharacterized protein Dmel_CG7236, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRD8
      Conserved Domains (2) summary
      cd07847
      Location:45 → 332
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
      pfam00069
      Location:47 → 332
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRD8 M9MRD8
    Q9VMN3 Q9VMN3
    X2J708 X2J708
    X2JD86 X2JD86

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