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    Syx18 Syntaxin 18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syx18provided by FlyBase
    Official Full Name
    Syntaxin 18provided by FlyBase
    Primary source
    FLYBASE:FBgn0039212
    Locus tag
    Dmel_CG13626
    See related
    AllianceGenome:FB:FBgn0039212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13626; Dm Ufe1; Dmel\CG13626; DmSyx18; Gtaxin; gtx; Syx; syx18; Ufe1/Syntaxin 18
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in neuromuscular junction development; neuromuscular synaptic transmission; and regulation of vesicle-mediated transport. Located in cell cortex and neuromuscular junction. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval neuromuscular junction; embryonic/larval salivary gland; and garland cell primordium. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syx18 in Genome Data Viewer
    Location:
    96A12-96A13; 3-85 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24623802..24625562, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20449524..20451284, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene molting defective Neighboring gene long non-coding RNA:CR46095 Neighboring gene atlastin Neighboring gene wsck Neighboring gene Metallothionein F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The duration of caffeine treatment plays an essential role in its effect on sleep and circadian rhythm. Segu A, et al. Sleep Adv, 2023. PMID 37193284, Free PMC Article
    2. Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin. Gorczyca D, et al. J Neurosci, 2007 Jan 31. PMID 17267557, Free PMC Article
    3. Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport. Lakatos Z, et al. Cells, 2019 Jul 24. PMID 31344970, Free PMC Article
    4. Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development. Lee M, et al. Dev Biol, 2009 Jun 15. PMID 19341724
    5. Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction. Lee HG, et al. Dev Neurobiol, 2013 Oct. PMID 23592328, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin 18
    Names
    CG13626-PA
    Syx18-PA
    gtaxin
    syntaxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24623802..24625562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079761.4 → NP_524485.1  syntaxin 18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC58
      Related
      FBpp0084050
      Conserved Domains (2) summary
      cd15850
      Location:306 → 364
      SNARE_syntaxin18; SNARE motif, subgroup Qa
      pfam10496
      Location:2 → 90
      Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC58 Q9VC58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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