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    CG13744 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13744provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033363
    Locus tag
    Dmel_CG13744
    See related
    AllianceGenome:FB:FBgn0033363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP67; cSP67; Dmel\CG13744; SP67
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to several human genes including PRSS21 (serine protease 21); PRSS41 (serine protease 41); and TMPRSS11B (transmembrane serine protease 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13744 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9014368..9017195, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4901873..4904700, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Notopleural Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. Nam HJ, et al. EMBO J, 2012 Mar 7. PMID 22227521, Free PMC Article
    2. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
    3. Identification and functional analysis of healing regulators in Drosophila. Álvarez-Fernández C, et al. PLoS Genet, 2015. PMID 25647511, Free PMC Article
    4. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
    5. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13744-PA
    NP_610439.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9014368..9017195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136595.2 → NP_610439.1  uncharacterized protein Dmel_CG13744 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7M5
      Related
      FBpp0087747
      Conserved Domains (2) summary
      smart00020
      Location:141 → 380
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:142 → 383
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7M5 A1Z7M5

    Gene LinkOut

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