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    Syb Synaptobrevin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36080, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sybprovided by FlyBase
    Official Full Name
    Synaptobrevinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003660
    Locus tag
    Dmel_CG12210
    See related
    AllianceGenome:FB:FBgn0003660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    21.15; c-Syb; CG12210; Dmel\CG12210; dVAMP; END1-2; J; l(2)46CFq; l(2)46El; n-syb; syb; SYB; synaptobrevin; Vamp; VAMP; VAMP2
    Summary
    Enables SNARE binding activity. Involved in positive regulation of vesicle fusion and vesicle fusion. Predicted to be located in synaptic vesicle. Predicted to be part of SNARE complex. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult digestive system; adult head; adult heart; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syb in Genome Data Viewer
    Location:
    46F8-46F8; 2-62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10249435..10252417, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6136940..6139922, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Histidine decarboxylase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chondroitin sulfate N-acetylgalactosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR30009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of transcripts from syb, a Drosophila melanogaster gene encoding VAMP (synaptobrevin) that is abundant in non-neuronal cells. Chin AC, et al. Gene, 1993 Sep 15. PMID 8406010
    2. A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Südhof TC, et al. Neuron, 1989 May. PMID 2560644
    3. Cysteine-string protein: the chaperone at the synapse. Chamberlain LH, et al. J Neurochem, 2000 May. PMID 10800920
    4. SNARE interactions in membrane trafficking: a perspective from mammalian central synapses. Kavalali ET. Bioessays, 2002 Oct. PMID 12325125
    5. A post-docking role for synaptobrevin in synaptic vesicle fusion. Hunt JM, et al. Neuron, 1994 Jun. PMID 8011337

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function.
      Title: Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function.
    2. Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion
      Title: Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.
    3. Expression of syb can restore synaptic transmission to n-syb mutants as assayed both by electroretinogram and recordings of excitatory junctional currents at the neuromuscular junction.
      Title: Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables SNAP receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptobrevin
    Names
    CG12210-PA
    CG12210-PB
    CG12210-PC
    CG12210-PD
    CG12210-PE
    Syb-PA
    Syb-PB
    Syb-PC
    Syb-PD
    Syb-PE
    VAMP3
    Vesicle-associated membrane protein
    complementation group J

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10249435..10252417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078956.4 → NP_523680.1  synaptobrevin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUB1
      Related
      FBpp0087450
      Conserved Domains (1) summary
      cd15870
      Location:23 → 85
      R-SNARE_VAMP2; SNARE motif of VAMP2

    2. NM_001144162.2 → NP_001137634.1  synaptobrevin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18489
      Conserved Domains (2) summary
      cd15870
      Location:23 → 85
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:22 → 109
      Synaptobrevin; Synaptobrevin

    3. NM_001144161.2 → NP_001137633.1  synaptobrevin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137633.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZD5, B7YZD6, P18489, Q3HKB4, Q8MKX1, Q9V5I6
      Conserved Domains (1) summary
      pfam00957
      Location:44 → 130
      Synaptobrevin

    4. NM_165756.3 → NP_724906.1  synaptobrevin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18489
      Related
      FBpp0087451
      Conserved Domains (2) summary
      cd15870
      Location:46 → 108
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:45 → 132
      Synaptobrevin; Synaptobrevin

    5. NM_001299349.1 → NP_001286278.1  synaptobrevin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286278.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUB1
      Conserved Domains (1) summary
      cd15870
      Location:23 → 85
      R-SNARE_VAMP2; SNARE motif of VAMP2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H1UUB1 H1UUB1
    P18489.3 P18489

    Gene LinkOut

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