Ntf-2 Nuclear transport factor-2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ntf-2provided by FlyBase
Official Full Name: Nuclear transport factor-2provided by FlyBase
Primary source: FLYBASE:FBgn0031145
Locus tag: Dmel_CG1740
See related: AllianceGenome:FB:FBgn0031145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM08921; CG1740; Dmel\CG1740; dmNTF2; Dntf-2; DNTF-2; Dntf2; l(1)G0086; l(1)G0125; l(1)G0337; l(1)G0428; ntf-2; NTF-2; ntf2; Ntf2
Summary: Predicted to enable nuclear import signal receptor activity. Involved in positive regulation of antimicrobial peptide biosynthetic process. Predicted to be part of nuclear pore central transport channel. Is expressed in adult head; organism; ovary; and testis. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 19E7-19E7; 1-65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (21035469..21041467)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20906496..20912494)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the possibility that Dntf-2r and ran-like might be involved in genomic conflicts during spermatogenesis
Title: Convergently recruited nuclear transport retrogenes are male biased in expression and evolving under positive selection in Drosophila.
Nuclear transport factor 2, specifically required in the development of the eye and in the immune response
Title: The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 21036959-21037289 mobile_element_type = transposon:INE-1{}5581

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of antimicrobial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear transport factor-2

Names: CG1740-PA; CG1740-PB; CG1740-PC; CG1740-PE; Ntf-2-PA; Ntf-2-PB; Ntf-2-PC; Ntf-2-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

21035469..21041467

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272821.1 → NP_001259750.1 nuclear transport factor-2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259750.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRD6

Conserved Domains (1) summary

cd00780
Location:6 → 125

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001272819.1 → NP_001259748.1 nuclear transport factor-2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259748.1

Status: REVIEWED

UniProtKB/TrEMBL

D0Z726

Conserved Domains (1) summary

cd00780
Location:1 → 84

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001103570.2 → NP_001097040.1 nuclear transport factor-2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097040.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUT4

Conserved Domains (1) summary

cd00780
Location:6 → 124

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_134578.3 → NP_608422.1 nuclear transport factor-2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608422.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRD6

Related

FBpp0076934

Conserved Domains (1) summary

cd00780
Location:6 → 125

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...