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    ssx sister-of-Sex-lethal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssxprovided by FlyBase
    Official Full Name
    sister-of-Sex-lethalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024987
    Locus tag
    Dmel_CG3056
    See related
    AllianceGenome:FB:FBgn0024987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey102; cg3056; CG3056; Dmel\CG3056; EG:132E8.1; Ssx
    Summary
    Enables RNA binding activity. Involved in defense response to bacterium; post-transcriptional gene silencing; and regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ssx in Genome Data Viewer
    Location:
    2A1-2A1; 1-0.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1370580..1375257)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1264613..1269290)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pan gu Neighboring gene uncharacterized protein Neighboring gene mir-4961 stem loop Neighboring gene AMP-activated protein kinase alpha subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing. Moschall R, et al. Nucleic Acids Res, 2019 Mar 18. PMID 30590805, Free PMC Article
    2. Drosophila Sister-of-Sex-lethal is a repressor of translation. Moschall R, et al. RNA, 2018 Feb. PMID 29089381, Free PMC Article
    3. Molecular evolution of Drosophila Sex-lethal and related sex determining genes. Mullon C, et al. BMC Evol Biol, 2012 Jan 14. PMID 22244243, Free PMC Article
    4. Phylogeny of the sex-determining gene Sex-lethal in insects. Traut W, et al. Genome, 2006 Mar. PMID 16604108
    5. The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade. Eirín-López JM, et al. Dev Genes Evol, 2015 Jan. PMID 25613749

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstration that Ssx safeguards male animals against Sxl protein production to reinforce a stable, male-specific gene expression pattern
      Title: Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing.
    2. Sister-of-Sex-lethal (Ssx) is a novel repressor of translation with Sxl-like activity.
      Title: Drosophila Sister-of-Sex-lethal is a repressor of translation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sister-of-Sex-lethal
    Names
    CG3056-PB
    CG3056-PC
    CG3056-PD
    CG3056-PE
    ssx-PB
    ssx-PC
    ssx-PD
    ssx-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1370580..1375257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297846.1 → NP_001284775.1  sister-of-Sex-lethal, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH14
      Conserved Domains (1) summary
      cl17169
      Location:93 → 173
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001297845.1 → NP_001284774.1  sister-of-Sex-lethal, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JA35
      Conserved Domains (1) summary
      cl17169
      Location:93 → 129
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_206603.3 → NP_996326.1  sister-of-Sex-lethal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH14
      Conserved Domains (1) summary
      cl17169
      Location:93 → 173
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_130552.3 → NP_569908.1  sister-of-Sex-lethal, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76876
      Related
      FBpp0308820
      Conserved Domains (1) summary
      cl17169
      Location:93 → 173
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76876 O76876
    Q8IH14 Q8IH14
    X2JA35 X2JA35

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