U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG42458 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768945, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG42458provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259935
    Locus tag
    Dmel_CG42458
    See related
    AllianceGenome:FB:FBgn0259935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg18656; CG18656; CG33277; CG33279; cg42458; Dmel\CG42458; HNPNPC
    Old locus tag
    Dmel_CG33277; Dmel_CG33279
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA stabilization. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in T4 neuron; T5 neuron; medullary tangential neuron Mt1; and transmedullary Y neuron TmY8. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including RALYL (RALY RNA binding protein like); HNRNPCL3 (heterogeneous nuclear ribonucleoprotein C like 3); and HNRNPCL4 (heterogeneous nuclear ribonucleoprotein C like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG42458 in Genome Data Viewer
    Location:
    65F11-66A1; 3-21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7423827..7454717)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7416927..7447817)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR33948 Neighboring gene long non-coding RNA:CR44525 Neighboring gene Rac2 Neighboring gene uncharacterized protein Neighboring gene sphinx1 Neighboring gene sphinx2 Neighboring gene uncharacterized protein Neighboring gene pickpocket 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 66A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines. Bollepogu Raja KK, et al. Nat Commun, 2023 Nov 8. PMID 37938573, Free PMC Article
    2. Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells. Appocher C, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28575377, Free PMC Article
    3. RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Ramesh N, et al. Acta Neuropathol Commun, 2020 Aug 18. PMID 32811564, Free PMC Article
    4. Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation. Tu R, et al. Curr Biol, 2021 Feb 22. PMID 33357404, Free PMC Article
    5. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, et al. Cell, 2018 Jul 26. PMID 29909983, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 7439807-7439873 mobile_element_type = transposon:INE-1{}6165

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG42458-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7423827..7454717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206288.4 → NP_996010.2  uncharacterized protein Dmel_CG42458 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996010.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A515MFZ2, Q7KU81
      Conserved Domains (2) summary
      COG0724
      Location:11 → 89
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12341
      Location:20 → 87
      RRM_hnRNPC_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein C (hnRNP C)-related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KU81 Q7KU81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous